Exploring Regions of Conformational Space Occupied by Two-Domain Proteins
Exploring Regions of Conformational Space Occupied by Two-Domain Proteins
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DOI：
10.1021/jp504820w
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发表时间：
2014-09-11
影响因子：
3.3
通讯作者：
Ravera, Enrico
中科院分区：
文献类型：
--
作者：
Andralojc, Witold;Luchinat, Claudio;Ravera, Enrico
The presence of heterogeneity in the interdomain arrangement of several biomolecules is required for their function. Here we present a method to obtain crucial clues to distinguish between different kinds of protein conformational distributions based on experimental NMR data. The method explores subregions of the conformational space and provides both upper and lower bounds of probability for the system to be in each subregion.
