Optimized multimodal functional magnetic resonance imaging/near-infrared spectroscopy probe for ultrahigh-resolution mapping.
Optimized multimodal functional magnetic resonance imaging/near-infrared spectroscopy probe for ultrahigh-resolution mapping.
复制标题
用于超高分辨率绘图的优化多模态功能磁共振成像/近红外光谱探头。
DOI：
10.1117/1.nph.2.4.045004
复制
发表时间：
2015
期刊：
影响因子：
5.3
通讯作者：
Frederick,Blaise
中科院分区：
文献类型：
--
作者：
Hocke,LiaMaria;Cayetano,Kenroy;Tong,Yunjie;Frederick,Blaise
功能近红外光谱（fNIRS）由于其高时间分辨率和独立测量氧和脱氧血红蛋白的能力，在神经科学中成为越来越重要的非侵入性方法。然而，fNIRS相对较低的空间分辨率使得很难将该信号与底层解剖结构联系起来。同时功能磁共振成像（fMRI）以其优越的空间分辨率和对整个大脑成像的能力补充了fNIRS，为提高fNIRS定位提供了额外的信息。然而，由于现有的MR线圈和fNIRS光电器件的物理兼容性较差，目前的fMRI/fNIRS同时采集方法并不是最优的。在这里，我们提出了一种制造真正的多模态fMRI/fNIRS探针的技术，其中两种模态都可以以最大的灵敏度使用。为了实现这一目标，我们使用三维打印设计了带有集成fNIRS光电器件的定制MR线圈。这种多模态探针可用于优化fMRI的空间（）和时间分辨率（2.5 Hz），并提供最大的MRI灵敏度，同时允许在感兴趣区域内fNIRS光电二极管的位置和密度具有高度灵活性。幻影和人体数据证实了两种模式下灵敏度的提高。这一探索显示了解决近红外光谱与生理学关系的基本问题的希望。
Functional near-infrared spectroscopy (fNIRS) is an increasingly important noninvasive method in neuroscience due to its high temporal resolution and ability to independently measure oxy- and deoxy-hemoglobin. However, the relatively low spatial resolution of fNIRS makes it difficult to relate this signal to underlying anatomy. Simultaneous functional magnetic resonance imaging (fMRI) can complement fNIRS with superior spatial resolution and the ability to image the entire brain, providing additional information to improve fNIRS localization. However, current simultaneous fMRI/fNIRS acquisition methods are not optimal, due to the poor physical compatibility of existing MR coils and fNIRS optodes. Here, we present a technique to manufacture a true multimodal fMRI/fNIRS probe in which both modalities can be used with maximal sensitivity. To achieve this, we designed custom MR coils with integral fNIRS optodes using three-dimensional printing. This multimodal probe can be used to optimize spatial () and temporal resolution (2.5 Hz) of fMRI, and it provides maximal MRI sensitivity, while allowing for high flexibility in the location and density of fNIRS optodes within the area of interest. Phantom and human data are shown to confirm the improvement in sensitivity in both modalities. This probe shows promise for addressing fundamental questions of the relation of fNIRS to physiology.