Nesfatin-1 stimulates renal sympathetic nerve activity in rats
Nesfatin-1 stimulates renal sympathetic nerve activity in rats
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DOI：
10.1097/wnr.0b013e328346107f
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发表时间：
2011-04
期刊：
影响因子：
1.7
通讯作者：
M. Tanida;M. Mori
中科院分区：
文献类型：
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作者：
M. Tanida;M. Mori
早期的研究报告称，中枢注射nesfatin-1可升高清醒大鼠的血压并抑制其摄食。在这项研究中，我们分析了侧脑室注射nesfatin-1对交感神经流出到肾脏的麻醉大鼠的影响。侧脑室注射nesfatin-1可显著刺激肾交感神经活动，并呈剂量依赖性升高血压。此外，我们研究了黑皮质素系统对nesfatin-1注射引起的交感兴奋的作用。用黑素皮质素-3/4受体拮抗剂SHU 9119预处理，消除了nesfatin-1引起的神经活动和血压的增加。因此，nesfatin-1给药对肾脏交感神经活性的刺激作用可能取决于中枢黑皮质素系统。
Earlier examination reported that central injection of nesfatin-1 elevated blood pressure and suppressed food intake in conscious rats. In this study, we analyzed the effects of the intracerebroventricular injection of nesfatin-1 on the sympathetic nerve outflow to the kidney in urethane-anesthetized rats. An intracerebroventricular injection of nesfatin-1 significantly stimulated renal sympathetic nerve activity and blood pressure in a dose-dependent manner. Moreover, we examined the role of the melanocortin system on the sympathoexcitation caused by the nesfatin-1 injection. Pretreatment with the melanocortin-3/4 receptor antagonist, SHU9119, abolished the increase in nerve activity and blood pressure induced by nesfatin-1. Thus, the stimulating effects of nesfatin-1 administration on the sympathetic nerve activity of the kidney may depend on the central melanocortin system.