Emergence of Tigecycline and Colistin Resistance in Acinetobacter Species Isolated from Patients in Kuwait Hospitals
Emergence of Tigecycline and Colistin Resistance in Acinetobacter Species Isolated from Patients in Kuwait Hospitals
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DOI：
10.1179/joc.2011.23.1.13
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发表时间：
2011-02-01
影响因子：
1.8
通讯作者：
Rotimi, V. O.
中科院分区：
文献类型：
--
作者：
Al-Sweih, N. A.;Al-Hubail, M. A.;Rotimi, V. O.
抵抗力的发展是。一个令人信服的理由来审查抗生素的管理。最近，大多数不动杆菌感染是由多药耐药（MDR）菌株引起的，因此需要使用替加环素或粘菌素。本研究旨在确定不动杆菌属的敏感性。这些和其他药物。在6个月内，从8家政府医院共收集了250株不动杆菌。采用E试验法测定替加环素、粘菌素等18种抗生素的最低抑菌浓度。在250株分离株中，13.6%和12%的菌株对替加环素和粘菌素耐药。亚胺培南和美罗培南耐药率分别为25.2%和37.2%。250株耐药菌株中88.4%为MDR。替加环素和粘菌素耐药分离株的相对较高患病率表明出现了可能严重影响MDR不动杆菌属治疗的新治疗问题。科威特的感染。
The development of resistance is. a compelling reason for reviewing administration of antibiotics. Recently, most Acinetobacter infections are caused by multidrug-resistant (MDR) strains which have necessitated the use of tigecycline or colistin. This study was undertaken to determine the susceptibility of Acinetobacter spp. to these and other drugs. A total of 250 Acinetobacter isolates were collected from the 8 government hospitals over a period of 6 months. Susceptibility to 18 antibiotics, including tigecycline and colistin, was investigated by determining their minimum inhibitory concentrations using E test. Of the 250 isolates, 13.6% and 12% were resistant to tigecycline and colistin. A total of 25.2% and 37.2% were resistant to imipenem and meropenem, respectively. Of the 250 isolates 88.4% were MDR. This relatively high prevalence of tigecycline and colistin-resistant isolates indicates an emerging therapeutic problem which may severely compromise the treatment of MDR Acinetobacter spp. infections in Kuwait.