Molecular evolution of the Myb family of transcription factors: Evidence for polyphyletic origin
Molecular evolution of the Myb family of transcription factors: Evidence for polyphyletic origin
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DOI：
10.1007/pl00006285
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发表时间：
1998-01-01
影响因子：
3.9
通讯作者：
Atchley, WR
中科院分区：
文献类型：
--
作者：
Rosinski, JA;Atchley, WR
Myb蛋白家族是一组在植物和动物中发现的功能多样的转录激活因子，其特征在于约50个氨基酸的保守DNA结合结构域。对该蛋白质家族的氨基酸序列的系统发育分析描绘了植物和动物中非常不同的进化历史。动物Myb蛋白从一个共同的祖先分化而来，而植物似乎只在DNA结合结构域内相关。结果意味着一个模式的模块化的Myb蛋白质的进化集中在拥有一个螺旋-转角-螺旋基序。基于这一点，它建议Myb蛋白是一个多系群相关的“Myb盒”DNA结合基序。
The Myb family of proteins is a group of functionally diverse transcriptional activators found in both plants and animals that is characterized by a conserved DNA-binding domain of approximately 50 amino acids. Phylogenetic analyses of amino acid sequences of this family of proteins portray very disparate evolutionary histories in plants and animals. Animal Myb proteins have diverged from a common ancestor, while plants appear related only within the DNA-binding domain. Results imply a pattern of modular evolution of the Myb proteins centering on the possession of a helix-turn-helix motif. Based on this it is suggested that Myb proteins are a polyphyletic group related only by a "Myb-box" DNA-binding motif.