Characterizing weekly self-reported antihypertensive medication nonadherence across repeated occasions.
Characterizing weekly self-reported antihypertensive medication nonadherence across repeated occasions.
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DOI：
10.2147/ppa.s60715
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发表时间：
2014
影响因子：
2.2
通讯作者：
Yancy WS Jr
中科院分区：
文献类型：
--
作者：
Voils CI;King HA;Neelon B;Hoyle RH;Reeve BB;Maciejewski ML;Yancy WS Jr
对于人与人之间以及人体内药物不依从性的每周变化知之甚少。描述重复、间隔紧密的场合中药物不依从性的特征。这项前瞻性队列研究包括四次未经通知的电话评估，每次间隔约两周。每次，服用至少一种抗高血压药物的成年门诊患者都会完成对不依从程度和原因的测量。 261 名参与者完成了 1,044 次中的 871 次（83%）。 261 名参与者中的 93 名 (36%) 报告了 871 次中的 152 次 (17.5%) 不遵守规定。最常见的不遵守的原因是忘记（39.5%）、忙碌（23.7%）和旅行（19.7%）。在至少完成 3 次的 219 名参与者中，不遵守程度的差异有 50% 是人内波动的结果，50% 是人与人之间差异的结果。减少不依从性的干预措施应根据不依从性程度的变化和不依从性的具体原因来制定。
Little is known about weekly variability in medication nonadherence both between and within persons. To characterize medication nonadherence across repeated, closely spaced occasions. This prospective cohort study comprised four unannounced telephone assessment occasions, each separated by approximately 2 weeks. On each occasion, adult outpatients taking at least a single antihypertensive medication completed a measure of extent of, and reasons for, nonadherence. Two hundred and sixty-one participants completed 871 (83%) of 1,044 occasions. Nonadherence was reported on 152 (17.5%) of 871 occasions by 93 (36%) of 261 participants. The most commonly endorsed reasons for nonadherence were forgetting (39.5%), being busy (23.7%), and traveling (19.7%). Among 219 participants completing at least three occasions, 50% of the variability in extent of nonadherence was a result of within-person fluctuations, and 50% was a result of between-person differences. Interventions to reduce nonadherence should be informed by variability in the extent of nonadherence and specific reasons for nonadherence.