Partial alignment of biomolecules: an aid to NMR characterization.
Partial alignment of biomolecules: an aid to NMR characterization.
复制标题
生物分子的部分排列：核磁共振表征的辅助。
DOI：
10.1016/s1367-5931(00)00247-7
复制
发表时间：
2001
影响因子：
7.8
通讯作者：
Kishore,AI
中科院分区：
文献类型：
--
作者：
Prestegard,JH;Kishore,AI
生物分子在溶液中的部分排列为高分辨率NMR方法的结构研究增加了一个新的维度。现在，蛋白质、核酸和碳水化合物的应用比比皆是。最初与生物分子与通常用于实现对准的液晶介质的相容性相关的限制已经开始消失。这在一定程度上是由于采用了各种各样的新媒体。未来的应用，生物学上的重要问题，如多结构域蛋白质的结构组织和多蛋白质组装看起来非常有前途。
Partial alignment of biomolecules in solution has added a new dimension to structural investigation by high-resolution NMR methods. Applications to proteins, nucleic acids and carbohydrates now abound. Limitations initially associated with compatibility of biomolecules with the liquid-crystal media commonly used to achieve alignment have begun to disappear. This is, in part, a result of the introduction of a wide variety of new media. Future applications to biologically important problems such as the structural organization of multi-domain proteins and multi-protein assemblies look very promising.