Measurement of urine pH for epidemiological studies on bladder cancer
Measurement of urine pH for epidemiological studies on bladder cancer
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DOI：
10.1007/s10654-006-9101-2
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发表时间：
2007-02-01
影响因子：
13.6
通讯作者：
Garcia-Closas, Montserrat
中科院分区：
文献类型：
--
作者：
Alguacil, Juan;Pfeiffer, Ruth M.;Garcia-Closas, Montserrat
尚未评估在流行病学和临床研究中有效识别持续酸性pH受试者的方法。我们招募了30名志愿者，以估计使用pH试纸进行尿液pH测量的最小次数，以确定“持续酸性尿液pH”受试者。用pH计和四种pH试纸测量的尿液pH值之间的斯皮尔曼相关系数范围为0.94 - 0.95（所有四种试纸的p < 0.001）。四个试纸和pH计之间的+/- 0.5 pH单位内的总体一致性范围为62.2%至74.4%。当使用一个早晨的现场尿液样本对参与者进行尿液pH值分类时，80%的人属于酸性尿液pH值（pH值等于或低于6.0）组。当我们要求受试者在连续6个上午点尿样和7个下午点尿样中尿液pH值等于或低于6.0时，只有20%的受试者符合这一标准。连续四天每天测量两次尿液pH值（清晨和傍晚），以与一周内每天测量两次相同的方式对个体进行分类。一个单一的pH值测量从现场尿样是不可靠的，以确定个人不断酸性pH值。晨，晚尿pH值测量与pH值条在连续四天确定个人不断酸性尿液pH值的个人以及一个星期的测量，因此可能是有用的，以确定受试者不断酸性尿液pH值的流行病学和临床研究。
Methods for efficiently identifying subjects with constantly acidic pH in epidemiological and clinical studies have not been assessed. We recruited 30 volunteers to estimate the minimum number of urine pH measurements using pH strips needed to identify subjects with "constantly acidic urine pH''. Spearman's correlation coefficients between urine pH measured with a pH meter and with the four pH strips ranged from 0.94 to 0.95 ( p < 0.001 for all four strips). Overall agreement within +/- 0.5 pH units between the four strips and the pH meter ranged from 62.2% to 74.4%. When using a spot urine sample from a single morning to classify participants with respect to their urine pH, 80% of individuals fell into the acidic urine pH ( pH equal to or lower than 6.0) group. When we required subjects to have urine pH equal to or lower than 6.0 in six consecutive AM spot urine samples and seven spot PM urine samples, only 20% of participants fulfilled this criterion. Measuring urine pH twice a day ( early in the morning and early in the evening) during four consecutive days classified individuals in the same way as two daily measurements for one week. A single pH measurement from a spot urine sample is not reliable to identify individuals with constantly acidic pH. Morning and evening urine pH measurements with pH strips during four consecutive days identify individuals with constantly acidic urine pH individuals as well as one week of measurements, and thus might be useful to identify subjects with constantly acidic urine pH in epidemiological and clinical studies.