Novel gonadal characteristics in an aged bovine freemartin
Novel gonadal characteristics in an aged bovine freemartin
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DOI：
10.1016/j.anireprosci.2014.02.011
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发表时间：
2014-04-01
影响因子：
2.2
通讯作者：
Brower, A. I.
中科院分区：
文献类型：
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作者：
Remnant, J. G.;Lea, R. G.;Brower, A. I.
对一只5岁的自由马丁荷斯坦动物的性腺进行了形态学分析和免疫组化，使用抗体对抗发育和功能标记。我们首次证明，抗苗勒管激素（AMH）产生的小管内细胞（支持细胞）在丰富的类固醇间质细胞的背景下保留，结构与黄体细胞簇一致。这篇新颖的报告描述了伴随这种新描述的性腺免疫表型的临床、大体和组织学发现，以及它在理解自由蛋白发育中的含义。(C) 2014年作者。Elsevier B.V.出版
The gonads from a five-year-old freemartin Holstein animal were subjected to morphological analysis and to immunohistochemistry using antibodies against developmental and functional markers. We demonstrate, for the first time, the retention of anti-mullerian hormone (AMH) producing intratubular cells (Sertoli cells) in the context of abundant steroidogenic interstitial cells, and structures consistent with clusters of luteal cells. This novel report describes the clinical, gross and histological findings accompanying this newly described gonadal immunophenotype, and its implication in the understanding of freemartin development. (C) 2014 The Authors. Published by Elsevier B.V.