Optimizing the benefits of bisphosphonates in osteoporosis : the importance of appropriate calcium intake.
Optimizing the benefits of bisphosphonates in osteoporosis : the importance of appropriate calcium intake.
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DOI：
10.2165/00024677-200605060-00006
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Vanderschueren, Dirk
中科院分区：
文献类型：
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作者：
Boonen, Steven;Bouillon, Roger;Vanderschueren, Dirk
骨质疏松症是发病率、死亡率和医疗费用的主要原因。如果不改进预防措施，骨质疏松症的社会经济负担可能会大幅增加。补钙有效地降低了绝经后妇女的骨丢失速度，但大多数妇女并没有达到足够的钙摄入量。事实上，随着更有效的抗吸收疗法，如双膦酸盐的出现，钙补充剂的使用似乎已经减少。在服用双磷酸盐的患者中，钙的摄入量通常是不足的，尽管可能需要足够的钙摄入量才能从抗吸收治疗中获得最大好处。此外，由于钙会干扰双膦酸盐的吸收，不正确地使用钙可能会限制双膦酸盐治疗的疗效。这强调了在抗吸收治疗过程中需要新的举措来减少围绕适当的钙使用的困惑。双膦酸盐与钙补充剂的联合包装是帮助确保服用双膦酸盐的患者不仅获得足够的钙摄入量，而且从双膦酸盐治疗中获得最大益处的一种策略。
Osteoporosis is a major cause of morbidity, mortality, and healthcare costs. The socioeconomic burden of osteoporosis is likely to increase dramatically if improvements in prevention are not made. Calcium supplementation effectively reduces the rate of bone loss in postmenopausal women, yet most women do not achieve an adequate calcium intake. In fact, use of calcium supplementation appears to have declined as the more effective antiresorptive therapies, such as bisphosphonates, have become available. Among patients prescribed bisphosphonates, calcium intake is often insufficient, despite the fact that adequate calcium intake may be necessary to gain the maximum benefits from antiresorptive therapy. In addition, because calcium interferes with bisphosphonate absorption, incorrect use of calcium may limit the efficacy of bisphosphonate therapy. This underscores the need for new initiatives to reduce the confusion surrounding appropriate calcium use during antiresorptive therapy. Co-packaging of bisphosphonates with calcium supplements is one strategy to help ensure that patients taking bisphosphonates not only achieve adequate calcium intake but also gain the maximum benefit from bisphosphonate therapy.