Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging
Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging
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DOI：
10.1016/j.bmcl.2007.10.013
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发表时间：
2007-12-15
影响因子：
2.7
通讯作者：
Pan, Dongfeng
中科院分区：
文献类型：
--
作者：
Zhang, Yi;Kundu, Bijoy;Pan, Dongfeng
将亲脂体特异性肽肉桂酰-F（D）LF（D）LFK（cFLFLFK）连续地与聚乙二醇部分（3.4 K）和2，2 '，2 "'，2“'-（1，4，7，10-四氮杂环十二烷-1，4，7，10-四基）四乙酸（DOTA）缀合以形成cFLFLFK-PEG-DOTA。在Cu-64标记后，正电子发射断层扫描（PET）成像能够成功地检测小鼠肺部炎症。(c)2007爱思唯尔有限公司保留所有权利。
A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4 K) and 2,2',2 '',2"'-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After Cu-64 labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation. (c) 2007 Elsevier Ltd. All rights reserved.