Superparamagnetic iron oxide hepatic MR imaging: efficacy and safety using conventional and fast spin-echo pulse sequences.
Superparamagnetic iron oxide hepatic MR imaging: efficacy and safety using conventional and fast spin-echo pulse sequences.
复制标题
超顺磁性氧化铁肝脏 MR 成像：使用传统和快速自旋回波脉冲序列的有效性和安全性。
DOI：
10.1002/jmri.1880050516
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Hooshmand,R
中科院分区：
文献类型：
--
作者：
Schwartz,LH;Seltzer,SE;Tempany,CM;Silverman,SG;Piwnica-Worms,DR;Adams,DF;Herman,L;Herman,LA;Hooshmand,R
本研究的目的是评估静脉注射 Ferumozldes (Feridexa) 的技术有效性和安全性，这是一种超顺磁性氧化铁造影剂，用于使用传统自旋回波和快速自旋回波 MR 图像检测肝脏病变。对 25 名疑似局灶性肝脏病变的患者进行了签约前和对比后 MR 研究。评估了传统的 T1 和 T2 加权 MR 图像，以及快速自旋回波和脂肪抑制的快速自旋回波 MR 图像。对造影剂进行定量评估，获得肝脏、脾脏和选定肝脏病变的感兴趣区域测量值。还对脉冲序列的整体图像质量和病变检测的主观评估进行了主观评估。使用超顺磁性氧化铁造影剂导致所有脉冲序列上的肝脏信号强度降低。在常规 T2、快速自旋回波和脂肪抑制快速自旋回波脉冲序列上，病灶与肝脏对比度分别增加了 41.1%、36.5% 和 32.0%。 T1 加权后造影脉冲序列上的病灶与肝脏对比度下降了 23.8%。尽管病灶与肝脏的对比度有所改善，但放射科医生主观上更喜欢预收缩序列，因为整体图像质量更好。在 10 μmol/kg 的剂量下，fenunoxas 有利地影响病变与肝脏的对比度，并且可能在肝脏成像中有用，对于传统的 T2 加权自旋回波脉冲序列比 T2 加权快速自旋回波脉冲序列更有用。
The purpose of this study was to evaluate the technical efficacy and safety of iv ferumozldes (Feridexa), a superparamagnetic iron oxide contrast agent for detection of hepatic lesions using conventional spin‐echo and fast spin‐echo MR images. Precontract and postcontrast MR studies were performed on 25 patients with suspected focal hepatic lesions. Conventional Tl‐and T2‐weighted MR images, as well as fast spin‐echo and fat suppressed fast spin‐echo MR images, were evaluated. Quantitative assessment of the contrast agent was performed obtaining region of interest measurements of the liver, spleen, and selected hepatic lesions. The pulse sequences were also evaluated subjectively for overall image quality and a subjective assessment of lesion detection. The use of a superparamagnetic iron oxide contrast agent led to a decrease in hepatic signal intensity on all pulse sequences. Lesion‐to‐liver contrast increased 41.1%, 36.5%, and 32.0% on the conventional T2, fast spin‐echo, and fat suppressed fast spin echo pulse sequences, respectively. Lesion‐to‐liver contrast decreased on the T1‐weighted postcontrast pulse sequence by 23.8%. Despite Improvement in lesion‐to‐liver contrast, radiologists subjectively preferred the precontract sequences because of overall better image quality. At a dose of 10 μmol/kg, fenunoxides favorably impacts lesion‐to‐liver contrast, and may be useful in hepatic imaging, more with conventional T2‐weighted spin‐echo pulse sequences than with T2‐weighted fast spin‐echo pulse sequences.