A reconsideration of the relation of ventricular enlargement to duration of illness in schizophrenia.
A reconsideration of the relation of ventricular enlargement to duration of illness in schizophrenia.
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重新考虑精神分裂症心室扩大与病程的关系。
DOI：
10.1176/ajp.140.12.1564
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
J. Wolf
中科院分区：
文献类型：
--
作者：
B. Woods;J. Wolf
对19例住院的青年慢性精神分裂症患者和29例同龄对照者的脑室大小进行了比较。患者的双尾状核比率略大，但明显更大。这些结果的背景下，以前的研究心室大小和精神分裂症的分析表明，与目前的观点相反，有一个直接的关系心室大小和精神分裂症的病程。作者认为，心室大小和精神分裂症的不同研究的相互矛盾的结果可以通过假设临床精神分裂症和心室扩大都是遗传性和进行性的潜在神经元变性的明显迹象来调和。
The size of the ventricles of 19 young hospitalized patients with chronic schizophrenia was compared with that of 29 same-age control subjects. The patients had a slightly but significantly larger bicaudate ratio. Analysis of these results in the context of previous studies of ventricular size and schizophrenia suggests that, contrary to current views, there is a direct relationship between size of ventricles and duration of schizophrenic illness. The authors argue that the conflicting results of different studies of ventricular size and schizophrenia can be reconciled by postulating that both clinical schizophrenia and ventricular enlargement are overt signs of an underlying neuronal degeneration that is hereditary and progressive.