Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
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DOI：
10.1042/cs20171620
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发表时间：
2018-04-30
期刊：
影响因子：
--
通讯作者：
Work LM
中科院分区：
文献类型：
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作者：
Horsburgh K;Wardlaw JM;van Agtmael T;Allan SM;Ashford MLJ;Bath PM;Brown R;Berwick J;Cader MZ;Carare RO;Davis JB;Duncombe J;Farr TD;Fowler JH;Goense J;Granata A;Hall CN;Hainsworth AH;Harvey A;Hawkes CA;Joutel A;Kalaria RN;Kehoe PG;Lawrence CB;Lockhart A;Love S;Macleod MR;Macrae IM;Markus HS;McCabe C;McColl BW;Meakin PJ;Miller A;Nedergaard M;O'Sullivan M;Quinn TJ;Rajani R;Saksida LM;Smith C;Smith KJ;Touyz RM;Trueman RC;Wang T;Williams A;Williams SCR;Work LM
脑血管病（SVD）是中风、认知障碍和痴呆的主要诱因，治疗干预措施有限。有一个关键的需要，提供机制的洞察力和改善临床前研究和临床之间的翻译。举办了为期两天的讲习班，汇集了来自脑血管疾病、痴呆和心血管生物学等多个学科的专家，重点介绍了这些领域的最新进展，探讨了协同作用和发展空间。这些会议记录提供了研讨会上主要讨论的总结，特别关注脑血管疾病和痴呆的动物模型，机制和改进翻译的方法。总结了相关主题讨论小组的结果，以确定知识差距和推进知识的需求。
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.