Modulating Repolarization of Tumor-Associated Macrophages with Targeted Therapeutic Nanoparticles as a Potential Strategy for Cancer Therapy.
Modulating Repolarization of Tumor-Associated Macrophages with Targeted Therapeutic Nanoparticles as a Potential Strategy for Cancer Therapy.
复制标题
用靶向治疗性纳米颗粒调节肿瘤相关巨噬细胞的复极化作为癌症治疗的潜在策略。
DOI：
10.1021/acsabm.1c00461
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发表时间：
2021-07
影响因子：
4.7
通讯作者：
Xiaojie Lin;Yan Fang;Xuechao Jin;Mingming Zhang;K. Shi
中科院分区：
文献类型：
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作者：
Xiaojie Lin;Yan Fang;Xuechao Jin;Mingming Zhang;K. Shi
肿瘤微环境（TME）中总有一些成分，例如肿瘤相关巨噬细胞（TAM），可以帮助肿瘤细胞逃避人体的免疫监视。因此，这种情况会导致肿瘤生长、进展和转移，导致癌症治疗的反应率低。巨噬细胞具有很强的可塑性和功能多样性，发挥着重要作用。面对不同的微环境刺激，巨噬细胞的表型和功能发生动态变化，形成两种主要的巨噬细胞亚群，即经典激活/炎症（M1）型和替代激活/再生（M2）型。通过各种信号通路，巨噬细胞极化成复杂的群体，可以执行不同的免疫功能。在这篇综述中，我们强调基于 TAM 表型的病理知识，使用纳米制剂进行巨噬细胞相关免疫治疗。这些巨噬细胞靶向纳米颗粒通过减弱 M2 巨噬细胞并减少对 TME 的聚集来重新编辑和重新教育巨噬细胞，从而缓解或减轻免疫抑制。其中，我们详细描述了涉及巨噬细胞可塑性和极化功能的几个主要信号通路的细胞机制和调节因子。阐明了这些途径的纳米治疗药物的优势和挑战，为以巨噬细胞为中心的各种疾病的诊断和治疗策略提供了基础和见解。
There are always some components in the tumor microenvironment (TME), such as tumor-associated macrophages (TAMs), that help tumor cells escape the body's immune surveillance. Therefore, this situation can lead to tumor growth, progression, and metastasis, resulting in low response rates for cancer therapy. Macrophages play an important role with strong plasticity and functional diversity. Facing different microenvironmental stimulations, macrophages undergo a dynamic change in phenotype and function into two major macrophage subpopulations, namely classical activation/inflammation (M1) and alternative activation/regeneration (M2) type. Through various signaling pathways, macrophages polarize into complex groups, which can perform different immune functions. In this review, we emphasize the use of nanopreparations for macrophage related immunotherapy based on the pathological knowledge of TAMs phenotype. These macrophages targeted nanoparticles re-edit and re-educate macrophages by attenuating M2 macrophages and reducing aggregation to the TME, thereby relieving or alleviating immunosuppression. Among them, we describe in detail the cellular mechanisms and regulators of several major signaling pathways involved in the plasticity and polarization functions of macrophages. The advantages and challenges of those nanotherapeutics for these pathways have been elucidated, providing the basis and insights for the diagnosis and treatment strategies of various diseases centered on macrophages.