Perinatal changes of brain-derived neurotrophic factor in pre- and fullterm neonates
Perinatal changes of brain-derived neurotrophic factor in pre- and fullterm neonates
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DOI：
10.1016/j.earlhumdev.2003.10.002
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发表时间：
2004-01-01
影响因子：
2.5
通讯作者：
Boutsikou, T
中科院分区：
文献类型：
--
作者：
Malamitsi-Puchner, A;Economou, E;Boutsikou, T
背景：脑源性神经营养因子(BDNF)在大脑和周围神经中含量丰富，影响正常发育、生长和生存，并参与免疫反应。目的：测定单个早产儿(P)和足月儿(F)宫内外循环中脑源性神经营养因子(BDNF)的水平，推测其神经和免疫成熟程度。研究设计：前瞻性研究。研究对象：30名健康的适龄胎龄(AGA)女性(平均胎龄39.2+/-1.4周)，15名健康AGA-P(29.4+/-1.3周)及其母亲。观察指标：用酶免疫法测定第一产程母亲(MS)、脐带(UC)及新生儿产后第1天(N1)、第4天(N4)血清中BDNF的含量。结果：(A)FMS组与PMS组BDNF水平无明显差异，但均显著高于UC、N1和N4组(p<0.05)。
Background: Brain-derived neurotrophic factor (BDNF) is abundant in brain and peripheral nerves, affects normal development, growth and survival and is implicated in immune response. Aim: To determine in single preterm (P) and fullterm (F) neonates, circulating intra- and extrauterine levels of BDNF, supposingly reflecting their neuronal and immune maturity. Study design: Prospective study. Subjects: Thirty healthy, appropriate for gestational age (AGA) F (mean gestational age 39.2 +/- 1.4 weeks), 15 healthy AGA P (29.4 +/- 1.3 weeks), and their mothers. Outcome measures: BDNF was measured by enzyme immunoassay methods in the serum of: mothers at the first stage of labor (MS), the umbilical cord (UC) and the neonates on days 1 (N1) and 4 (N4) postpartum. Results: Levels of BDNF in (a) FMS did not differ from PMS, but both were significantly higher than respective (F or P) UC, N1 and N4 (p ranging from