Pneumocystis carinii host origin defines the antibody specificity and protective response induced by immunization
Pneumocystis carinii host origin defines the antibody specificity and protective response induced by immunization
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DOI：
10.1086/514128
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发表时间：
1997-11-01
影响因子：
6.4
通讯作者：
Harmsen, AG
中科院分区：
文献类型：
--
作者：
Gigliotti, F;Harmsen, AG
为了确定卡氏肺孢子虫的已知宿主物种特异性抗原变异将如何影响免疫识别，用小鼠或雪貂来源的卡氏肺孢子虫免疫小鼠，随后分析免疫应答和小鼠在免疫抑制和攻击后抵抗感染的能力。用小鼠来源的卡氏肺孢子虫免疫产生对小鼠而不是雪貂卡氏肺孢子虫的强烈免疫应答，这些小鼠在通过用小鼠卡氏肺孢子虫体内接种进行攻击时完全免于卡氏肺孢子虫肺炎。相反，用雪貂卡氏肺孢子虫免疫产生对小鼠卡氏肺孢子虫的有限抗体应答，并且没有保护作用。这些结果表明，来自不同宿主物种的卡氏肺孢子虫在免疫学上是不同的，并且任何可能用于人类卡氏肺孢子虫肺炎的免疫疗法都必须考虑动物源卡氏肺孢子虫中这些生物学上显著的抗原差异。
To determine how the known host species-specific antigenic variation of Pneumocystis carinii would affect immune recognition, mice were immunized with either mouse-or ferret-derived P. carinii, with subsequent analysis of the immune response and the ability of the mice to resist infection after immunosuppression and challenge, Immunization with mouse-derived P. carinii produced a strong immune response to mouse but not ferret P. carinii, These mice were completely protected from P. carinii pneumonia when challenged by intratracheal inoculation with mouse P. carinii. In contrast, immunization with ferret P. carinii produced a limited antibody response to mouse P. carinii and had no protective effect, These results show that P. carinii from different host species are immunologically distinct, and any possible use of immunotherapy for P. carinii pneumonia in humans must take into consideration these biologically significant antigenic differences in P. carinii of animal origin.