Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection
Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection
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DOI：
10.1371/journal.pone.0210132
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发表时间：
2019-01-16
期刊：
影响因子：
3.7
通讯作者：
Wakim, Linda M.
中科院分区：
文献类型：
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作者：
Bedford, James G.;O'Keeffe, Meredith;Wakim, Linda M.
干扰素诱导的跨膜蛋白3(IFITM3)是一种有效的抗病毒蛋白，可增强细胞对包括流感病毒在内的各种病原体的抵抗力。经典的定义是干扰素刺激基因，IFITM3在细胞上的表达在I型和II型干扰素的响应下迅速上调。在这里，我们发现IFITM3在T细胞被激活后迅速上调，这种上调不依赖于I型和II型干扰素以及干扰素调节因子3和7。在效应型T细胞上上调IFITM3保护这些细胞免受病毒感染，并在病毒感染部位赋予生存优势。我们的结果表明，IFITM3在效应器T细胞上的表达对这些细胞介导其效应器功能至关重要，并强调了诱导IFITM3的干扰素非依赖途径，如果靶向，这可能是利用IFITM3的活性来预防感染的有效途径。
Interferon-induced transmembrane protein 3 (IFITM3) is a potent antiviral protein that enhances cellular resistance to a variety of pathogens, including influenza virus. Classically defined as an interferon-stimulated gene, expression of IFITM3 on cells is rapidly up-regulated in response to type I and II interferon. Here we found that IFITM3 is rapidly up-regulated by T cells following their activation and this occurred independently of type I and II interferon and the interferon regulatory factors 3 and 7. Up-regulation of IFITM3 on effector T cells protected these cells from virus infection and imparted a survival advantage at sites of virus infection. Our results show that IFITM3 expression on effector T cells is crucial for these cells to mediate their effector function and highlights an interferon independent pathway for the induction of IFITM3 which, if targeted, could be an effective approach to harness the activity of IFITM3 for infection prevention.