A to I editing in disease is not fake news.
A to I editing in disease is not fake news.
复制标题
DOI：
10.1080/15476286.2017.1306173
复制
发表时间：
2017-09-02
期刊：
影响因子：
4.1
通讯作者：
O'Connell M
中科院分区：
文献类型：
--
作者：
Bajad P;Jantsch MF;Keegan L;O'Connell M
作用于RNA的腺苷脱氨酶（ADARs）是一种将转录本中dsRNA区域内的腺苷碱基脱氨为肌苷的含锌酶。简而言之，结构化的dsRNA可以锁定单个腺苷碱基，并以高达100%的效率进行编辑，从而产生替代蛋白质变体。然而，大多数编辑事件发生在由重复序列配对形成的较长dsRNA片段内。在这里，许多不同的腺苷碱基是潜在的目标，但编辑效率通常要低得多。最近的研究表明，adar介导的RNA编辑也需要防止检测细胞质中病毒dsRNA的抗病毒先天免疫传感器的异常激活。ADAR1 RNA编辑酶的错义突变在受影响的儿童中引起致命的自身炎症性疾病，aicardii - gouti<e:1>综合征（AGS）。此外，已经观察到ADARs对RNA的编辑在许多癌症中增加，并且还可能导致血管疾病。因此，RNA编辑在各种疾病进展中的作用不能再被忽视。ADARs改变RNA序列的能力也被用于体外和细胞中人工靶向模型RNA进行RNA编辑。这种方法可能用于修复遗传缺陷，并在RNA水平上改变遗传信息。在这篇综述中，我们主要关注ADARs在疾病发生和进展中的作用，以及它们在有针对性地人工修饰rna方面的潜在用途。
Adenosine deaminases acting on RNA (ADARs) are zinc-containing enzymes that deaminate adenosine bases to inosines within dsRNA regions in transcripts. In short, structured dsRNA hairpins individual adenosine bases may be targeted specifically and edited with up to one hundred percent efficiency, leading to the production of alternative protein variants. However, the majority of editing events occur within longer stretches of dsRNA formed by pairing of repetitive sequences. Here, many different adenosine bases are potential targets but editing efficiency is usually much lower. Recent work shows that ADAR-mediated RNA editing is also required to prevent aberrant activation of antiviral innate immune sensors that detect viral dsRNA in the cytoplasm. Missense mutations in the ADAR1 RNA editing enzyme cause a fatal auto-inflammatory disease, Aicardi–Goutières syndrome (AGS) in affected children. In addition RNA editing by ADARs has been observed to increase in many cancers and also can contribute to vascular disease. Thus the role of RNA editing in the progression of various diseases can no longer be ignored. The ability of ADARs to alter the sequence of RNAs has also been used to artificially target model RNAs in vitro and in cells for RNA editing. Potentially this approach may be used to repair genetic defects and to alter genetic information at the RNA level. In this review we focus on the role of ADARs in disease development and progression and on their potential use to artificially modify RNAs in a targeted manner.
登录
查看更多内容
朊病毒样聚合是抗病毒免疫防御和炎症小体激活中信号转导的基础。
影响因子：
64.5
作者：
Cai X;Chen J;Xu H;Liu S;Jiang QX;Halfmann R;Chen ZJ
通讯作者：
Chen ZJ
影响因子：
56.9
作者：
BRUSA, R;ZIMMERMANN, F;SPRENGEL, R
通讯作者：
SPRENGEL, R
影响因子：
4.8
作者：
Cenci, Caterina;Barzotti, Rita;Gallo, Angela
通讯作者：
Gallo, Angela
影响因子：
4.8
作者：
Hartner, JC;Schmittwolf, C;Seeburg, PH
通讯作者：
Seeburg, PH
AZIN1 的重新编码 RNA 编辑易诱发肝细胞癌。
影响因子：
82.9
作者：
通讯作者：
--