Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis
Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis
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DOI：
10.1093/jac/dkl007
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发表时间：
2006-04-01
影响因子：
5.2
通讯作者：
Cottagnoud, P
中科院分区：
文献类型：
--
作者：
Gerber, P;Stucki, A;Cottagnoud, P
目的：测试达托霉素（一种环脂肽抗生素）对实验性兔脑膜炎中甲氧西林敏感金黄色葡萄球菌菌株的功效，并确定其对非炎症和炎症脑膜的渗透性结果：在8小时的治疗期内，达托霉素（15 mg/kg）显著上级优于对照方案万古霉素（达托霉素为-4.54 +/- 1.12 log（10）/mL，而万古霉素为-3.43 +/- 1.17 log（10）/mL）。达托霉素对10个CSF中的6个成功灭菌，而万古霉素对10个CSF中的4个成功灭菌。达托霉素的渗透到发炎的脑膜是类似于5%和类似于2%到非发炎的menings.Conclusions：达托霉素的上级杀菌活性证实在体内和体外时间杀伤试验。
Objectives: To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meningesResults: Over a treatment period of 8 h, daptomycin (15 mg/kg) was significantly superior to the comparator regimen vancomycin (-4.54 +/- 1.12 log(10)/mL for daptomycin versus -3.43 +/- 1.17 log(10)/mL for vancomycin). Daptomycin managed to sterilize 6 out of 10 CSFs compared with 4 out of 10 for vancomycin. The penetration of daptomycin into inflamed meninges was similar to 5% and similar to 2% into non-inflamed meninges.Conclusions: The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.