TISSUE-SPECIFIC PERFUSION IMAGING USING ARTERIAL SPIN-LABELING
TISSUE-SPECIFIC PERFUSION IMAGING USING ARTERIAL SPIN-LABELING
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DOI：
10.1002/nbm.1940070112
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发表时间：
1994-03-01
影响因子：
2.9
通讯作者：
LEIGH, JS
中科院分区：
文献类型：
--
作者：
DETRE, JA;ZHANG, WG;LEIGH, JS
定量磁共振测量区域组织灌注可以使用磁标记动脉水作为扩散示踪剂。利用绝热反演实现了流动自旋的连续标记。连续标记近端动脉自旋和远端组织磁化中的T-1松弛的作用导致组织磁化的稳态变化，这种变化具有组织特异性，即可以以单位时间内每克组织的血流量为单位进行量化。使用标准成像序列对这种磁化进行采样。综述了该方法的理论基础，包括大分子自旋饱和度的影响。最近的结果表明，该技术在体外和体内成功地应用于大鼠脑、心脏和肾脏，以及人脑和肾脏，以及使用单独的射频线圈进行动脉标记，在大鼠脑中产生选择性灌注图像。这种方法可以在H-1 MRI分辨率下获得完全无创的定量灌注图像，并且在器官生理学的临床和研究评估中很有用。
Quantitative magnetic resonance measurements of regional tissue perfusion can be obtained using magnetically labeled arterial water as a diffusable tracer. Continuous labeling is achieved in flowing spins using adiabatic inversion. The effects of continuous labeling of proximal arterial spins and T-1 relaxation in distal tissue magnetization result in a steady-state change in tissue magnetization which is tissue specific, i.e., it can be quantified in units of blood flow per gram of tissue per unit time. This magnetization is sampled using standard imaging sequences. The theoretical basis for this method, including the effects of macromolecular spin saturation, is reviewed. Recent results demonstrating the successful implementation of this technique in vitro and in vivo in rat brain, heart, and kidney, and in human brain and kidney are presented, as well as the use of a separate RF coil for arterial labeling to produce selective perfusion images in rat brain. This approach allows quantitative perfusion images to be obtained completely non-invasively at the resolution of H-1 MRI, and is useful in the clinical and investigational evaluation of organ physiology.