The antidiabetic and hepatoprotective effects of myricitrin on aged mice with D-galactose.
The antidiabetic and hepatoprotective effects of myricitrin on aged mice with D-galactose.
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DOI：
10.22037/ghfbb.v13i3.1782
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发表时间：
2020-01-01
影响因子：
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通讯作者：
Ramezani-AliAkbari, Fatemeh
中科院分区：
文献类型：
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作者：
Omidi, Mina;Ahangarpour, Akram;Ramezani-AliAkbari, Fatemeh
目的：本研究旨在探讨杨梅苷对D-半乳糖（D-gal）致衰老小鼠的降糖和保肝作用。背景：衰老是人的一生中的事，没有任何方法可以阻止衰老过程，但抗氧化剂和改变生活方式可以延缓衰老（30 - 35 g）随机分为6组：1组为对照组，2组为D-半乳糖500 mg/kg/d组，3-5组为D-半乳糖+杨梅苷5、10、20 mg/kg/d组，6组为D-半乳糖+维生素E 100 mg/kg/d组。腹腔注射D-半乳糖诱导衰老45天。在过去28天内，通过灌胃经口给予杨梅苷和维生素E。结果：D-半乳糖注射液可使血糖升高（P < 0. 05），胰岛素水平升高（P < 0. 05），胰岛β细胞功能降低（P < 0. 05），胰岛素抵抗增加（P < 0. 05），肝酶、血脂水平升高（P < 0. 05），肝、胰腺组织学改变（P < 0. 05）。
AIM: The present study aims to evaluate the effects of antidiabetic and hepatoprotective of myricitrin in the aged mice induced by D-galactose (D-gal).BACKGROUND: Aging occurs during a person's life; there has been no way to stop the aging process, but antioxidant and changing lifestyles can delay it.METHODS: In this experimental study, 72 female adult mice (weighing30-35g) were randomly divided into six groups: 1: control, 2: D-gal at 500mg/kg/d, 3-5: D-gal+ Myricitrin at 5, 10 and 20mg/kg/d 6: D-gal+ Vitamin E at 100mg/kg/d. Aging induced by D-gal for 45 days via intraperitoneal. Myricitrin and Vitamin E administrated orally by gavage for the last 28 days. The blood glucose, insulin level, beta-cell function, insulin resistance, hepatic enzymes, lipid profile, and histology of the liver, and pancreas were evaluated.RESULTS: D-gal injection increased the glucose (p