Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition
Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition
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DOI：
10.1016/j.jep.2007.12.002
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发表时间：
2008-03-05
影响因子：
5.4
通讯作者：
Huang, Hua-Qiong
中科院分区：
文献类型：
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作者：
Shen, Hua-Hao;Wang, Kai;Huang, Hua-Qiong
哮喘是一种常见的肺部疾病，在世界范围内得到公认。迄今为止，人们对中药中的草药产品越来越感兴趣，认为其对治疗哮喘有效。黄芪（Astragalus Membranaceus，AM）是一种治疗过敏性疾病的中草药。本研究的目的是确定该中药注射液是否能抑制过敏性哮喘小鼠的AHR和粘液高分泌。材料与方法采用慢性哮喘小鼠模型，研究AM注射液对气道病变的影响，并与糖皮质激素进行比较。本研究在卵清蛋白致敏和激发的小鼠上进行，并进行全身体积描记以评估AHR。结果表明，AM给药28天可明显减少过敏小鼠肺组织的炎症浸润和粘液分泌。28-AM给药28 d可增强OVA诱导的IFN-γ水平下降，而IL-5和IL-13水平升高可被AM给药28 d所阻止。黄芪注射液28天后，可明显抑制过敏性哮喘小鼠AHR的升高。结论黄芪注射液对过敏性哮喘有潜在的治疗作用。
AIM OF THE STUDYAsthma is recognized as a common pulmonary disease throughout the world. To date, there has been a growing interest in herbal products in Traditional Chinese Medicine, which is considered to be effective to treat asthma. A Chinese herb Astragalus Membranaceus (AM) was found useful in treating allergic diseases. The purpose of this study is to determine whether this herbal injection could suppress allergic-induced AHR and mucus hypersecretion in allergic mice.MATERIALS AND METHODSA mouse model of chronic asthma was used to investigate AM injection on the airway lesions in compared with glucocorticoids. The study was conducted on mice sensitized and challenged with ovalbumin and the whole body plethsmography was performed to assess AHR. The bronchoalveolar lavage (BAL), histopathology were examined.RESULTSWe found 28-day AM administration significantly decreased inflammatory infiltration and mucus secretion in the lung tissues of allergic mice. 28-day AM administration enhanced Ova-induced decreased IFN-γ, and the Ova-induced elevations of IL-5 and IL-13 in BALF were prevented by 28-day injection. We also showed 28-day AM injection markedly suppressed increased AHR in allergic mice.CONCLUSIONSOur results indicate Astragalus Membranaceus has a potential role in treating allergic asthma.