Functional MRI at 1.5 tesla: A comparison of the blood oxygenation level-dependent signal and electrophysiology
Functional MRI at 1.5 tesla: A comparison of the blood oxygenation level-dependent signal and electrophysiology
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DOI：
10.1073/pnas.170205497
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发表时间：
2000-08-15
影响因子：
11.1
通讯作者：
Krubitzer, LA
中科院分区：
文献类型：
--
作者：
Disbrow, EA;Slutsky, DA;Krubitzer, LA
功能性磁共振成像（fMRI）信号在多大程度上反映了潜在的电生理学？尽管这项技术无处不在，但这个问题还没有得到充分的回答。因此，我们比较了基于fMRI的间接血氧水平依赖信号生成的皮层地图与直接测量神经活动的微电极记录技术的地图。在同一麻醉猕猴的两组实验中使用相同的体感刺激。我们的研究结果表明，功能磁共振成像可以用来确定的地形组织的皮层领域与55%的一致性，电生理地图。在垂直于局部血管的平面中，fMRI激活位置的变化最大。对功能磁共振成像局限性的认识提高了我们有效地利用它来研究大脑皮层组织的能力。
How well does the functional MRI (fMRI) signal reflect underlying electrophysiology? Despite the ubiquity of the technique, this question has yet to be adequately answered. Therefore, we have compared cortical maps generated based on the indirect blood oxygenation level-dependent signal of fMRI with maps from microelectrode recording techniques, which directly measure neural activity. Identical somatosensory stimuli were used in both sets of experiments in the same anesthetized macaque monkeys. Our results demonstrate that fMRI can be used to determine the topographic organization of cortical fields with 55% concordance to electrophysiological maps. The variance in the location of fMRI activation was greatest in the plane perpendicular to local vessels. An appreciation of the limitations of fMRI improves our ability to use it effectively to study cortical organization.