Beta2*nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
Beta2*nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
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DOI：
10.1093/ntr/ntq040
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发表时间：
2010-05-01
影响因子：
4.7
通讯作者：
Staley, Julie K.
中科院分区：
文献类型：
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作者：
Cosgrove, Kelly P.;Esterlis, Irina;Staley, Julie K.
简介：尼古丁和吸烟已显示出由含有 β2* 亚基 (β(2)*-nAChR) 的烟碱乙酰胆碱受体介导的抗伤害作用。在本研究中，我们使用 [(123)I]5-IA-85380 ([(123)I]5-IA) 和单光子发射计算机断层扫描 (SPECT) 脑成像检查了人类吸烟者急性戒断期间 β(2)*-nAChR 可用性和伤害感受之间的关系。方法：吸烟者（n = 24，年龄 34 +/- 11 岁）在急性戒断期间参与冷加压任务（最多 3 小时）以及在使用 [(123)I]5-IA SPECT 成像当天戒烟 7-13 天后进行的第二次冷加压任务。冷加压任务用于测量疼痛敏感性（当受试者首先感到疼痛时）和疼痛耐受性（当受试者无法承受疼痛时）。结果：戒烟 7-13 天后，疼痛敏感性增加，例如，吸烟时间缩短。首先感到疼痛与丘脑 (r = -.43)、顶叶 (r = -.50)、额叶 (r = -.55)、前扣带回 (r = -.44)、颞叶 (r = -.43) 和枕叶 (r = -.48) 皮质中较高的 β(2)*-nAChR 可用性显着相关。疼痛敏感性的百分比变化。第一至第二次冷加压任务与丘脑 (r = -.57)、小脑 (r = -.50)、纹状体 (r = -.057)、顶叶 (r = -.46)、前扣带回 (r = -.48)、颞叶 (r = -.55) 和枕叶 (r = -.57) 皮质中的 β(2)*-nAChR 可用性显着相关。在疼痛耐受性方面没有观察到类似的关联。讨论：这表明 β(2)*-nAChR 在戒烟期间的疼痛敏感性中发挥作用，但在疼痛耐受性中没有作用。如果个体更容易因疼痛刺激而复发，急性戒断期间较低的 β(2)*- nAChR 可用性可能具有保护作用。
Introduction: Nicotine and tobacco smoking administration have demonstrated antinociceptive effects that are mediated by the nicotinic acetylcholine receptor containing the beta2* subunit (beta(2)*-nAChR). In this study, we examined the relationship between beta(2)*-nAChR availability and nociception during acute withdrawal in human tobacco smokers using [(123)I]5-IA-85380 ([(123)I]5-IA) and single photon emission computed tomography (SPECT) brain imaging.Methods: Tobacco smokers (n = 24, aged 34 +/- 11 years) participated in the cold pressor task during acute withdrawal (up to 3 hr) and a second cold pressor task following 7-13 days of smoking abstinence on the day they were imaged with [(123)I]5-IA SPECT. The cold pressor task is used to measure pain sensitivity (when subjects. first feel pain) and pain tolerance (when subjects cannot withstand pain).Results: Following 7-13 days of tobacco smoking abstinence, increased pain sensitivity, for example, shorter time to. first feel pain, was significantly associated with higher beta(2)*-nAChR availability in the thalamus (r = -.43), parietal (r = -.50), frontal (r = -.55), anterior cingulate (r = -.44), temporal (r = -.43), and occipital (r = -.48) cortices. The percent change in pain sensitivity from the. first to second cold pressor task was significantly correlated with beta(2)*-nAChR availability in the thalamus (r = -.57), cerebellum (r = -.50), striatum (r = -.057), parietal (r = -.46), anterior cingulate (r = -.48), temporal (r = -.55), and occipital (r = -.57) cortices. Similar associations were not observed with pain tolerance.Discussion: This suggests that beta(2)*-nAChRs play a role in pain sensitivity but not pain tolerance during tobacco smoking withdrawal. If individuals are more likely to relapse in response to painful stimuli, lower beta(2)*- nAChR availability during acute abstinence may be protective.