Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: A preliminary study
Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: A preliminary study
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DOI：
10.1080/15622970903079499
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发表时间：
2009-01-01
影响因子：
3.1
通讯作者：
Le Foll, Bernard
中科院分区：
文献类型：
--
作者：
Novak, Gabriela;Boukhadra, Julien;Le Foll, Bernard
全基因组扫描研究最近发现 NRXN1 和 NRXN3 基因是尼古丁成瘾风险的潜在影响因素。我们对 195 名无关的精神分裂症患者的 NRXN1 和 NRXN3 基因的 15 个单核苷酸多态性 (SNP) 进行了基因分型，获得了这些患者的吸烟状况和每天吸烟数量 (CPD) 的信息。 NRXN3 标记 rs1004212 与吸烟量显着相关。 rs1004212 C 等位基因纯合的个体每天比杂合的个体吸更多的香烟。我们发现 NRXN1 基因内的标记与吸烟风险或吸烟量没有显着关联。由于样本量相对较小，这是一项初步研究。然而，这项候选基因研究支持了涉及 NRXN 基因与药物成瘾有关的分子研究的观察结果，并表明 NRXN3 基因的变异可能会导致精神分裂症患者对尼古丁的依赖程度。
Whole genome scan studies have recently identified the NRXN1 and NRXN3 genes as potential contributing factors in the risk for nicotine addiction. We have genotyped 15 single nucleotide polymorphisms (SNPs) spanning the NRXN1 and NRXN3 genes in 195 unrelated patients with schizophrenia for whom information about their smoking status and number of cigarettes smoked per day (CPD) was obtained. The NRXN3 marker rs1004212 was significantly associated with quantity of tobacco smoked. Individuals homozygous for the C allele of rs1004212 smoked more cigarettes per day than heterozygous individuals. We found no significant association of markers within the NRXN1 gene with the risk of smoking or the quantity of tobacco smoked. Because of the relatively small sample size, this is a preliminary study. However, this candidate gene study supports the observations of molecular studies implicating the NRXN genes in drug addiction and suggests that variants in the NRXN3 gene could contribute to the degree of nicotine dependence in patients with schizophrenia.