Relating MEG measured motor cortical oscillations to resting γ-aminobutyric acid (GABA) concentration.
Relating MEG measured motor cortical oscillations to resting γ-aminobutyric acid (GABA) concentration.
复制标题
DOI：
10.1016/j.neuroimage.2010.12.077
复制
发表时间：
2011-03-15
期刊：
影响因子：
5.7
通讯作者：
Roberts TP
中科院分区：
文献类型：
--
作者：
Gaetz W;Edgar JC;Wang DJ;Roberts TP
人类运动皮层表现出特征性的β（15-30 Hz）和γ振荡（60-90 Hz），通常在瞬时手指运动任务的背景下观察到。这些振荡的功能意义，如运动后β反弹（PMBR）和运动相关的γ同步（MRGS）仍然不清楚。然而，相当多的动物和人类非侵入性研究表明，支持这些运动皮层振荡的网络严重依赖于抑制性神经递质γ-氨基丁酸（GABA）。尽管有这样的推测，MEG测量的运动皮层振荡功率和频率与静息GABA浓度之间的直接关系尚未得到证实。在本研究中，运动皮层反应测量9名健康成人，而他们执行了一个提示按钮按下任务，用他们的右手食指。在每个参与者中，PMBR和MRGS的措施，从时间-频率图获得的主要电机（MI）的来源，使用波束形成器差分源定位。对于每个参与者，还获得了与左侧中央沟的运动手柄对齐的免费磁共振波谱（MRS）GABA测量。GABA浓度估计为运动皮质GABA积分与皮质参考NAA共振（2 ppm）的比值。M1区GABA浓度与MRGS频率呈显著线性相关（R2 = 0.46，p<0.05），而与MRGS功率无相关性。相反，在MI GABA浓度和PMBR功率之间观察到显著的线性关系（R2 = 0.34，p<0.05），而没有观察到GABA浓度和PMBR频率之间的关系。最后，观察到参与者的年龄和MI伽马频率之间的显著负线性关系，使得老年参与者具有较低的伽马频率（R2 = 0.40，p < 0.05）。目前的研究结果支持GABA在内源性运动皮质节律β和γ活动的产生和调制中的作用。
The human motor cortex exhibits characteristic beta (15-30 Hz) and gamma oscillations (60-90 Hz), typically observed in the context of transient finger movement tasks. The functional significance of these oscillations, such as post-movement beta rebound (PMBR) and movement-related gamma synchrony (MRGS) remain unclear. Considerable animal and human non-invasive studies, however, suggest that the networks supporting these motor cortex oscillations depend critically on the inhibitory neurotransmitter γ-Aminobutyric acid (GABA). Despite such speculation, a direct relation between MEG measured motor cortex oscillatory power and frequency with resting GABA concentrations has not been demonstrated. In the present study, motor cortical responses were measured from 9 healthy adults while they performed a cued button-press task using their right index finger. In each participant, PMBR and MRGS measures were obtained from time-frequency plots obtained from primary motor (MI) sources, localized using beamformer differential source localization. For each participant, complimentary magnetic resonance spectroscopy (MRS) GABA measures aligned to the motor hand knob of the left central sulcus were also obtained. GABA concentration was estimated as the ratio of the motor cortex GABA integral to a cortical reference NAA resonance at 2 ppm. A significant linear relation was observed between MI GABA concentration and MRGS frequency (R2 = 0.46, p<0.05), with no association observed between GABA concentration and MRGS power. Conversely, a significant linear relation was observed between MI GABA concentration and PMBR power (R2 = 0.34, p<0.05), with no relation observed for GABA concentration and PMBR frequency. Finally, a significant negative linear relation between the participant’s age and MI gamma frequency was observed, such that older participants had a lower gamma frequency (R2 = 0.40, p < 0.05). Present findings support a role for GABA in the generation and modulation of endogenous motor cortex rhythmic beta and gamma activity.
登录
查看更多内容
使用药物脑磁图确定人类皮质中 GABA 能调节的神经网络药效学。
影响因子：
4.8
作者：
Hall, Stephen D.;Barnes, Gareth R.;Furlong, Paul L.;Seri, Stefano;Hillebrand, Arjan
通讯作者：
Hillebrand, Arjan
影响因子：
14.5
作者：
Yousry, TA;Schmid, UD;Winkler, P
通讯作者：
Winkler, P
影响因子：
5.7
作者：
Jurkiewicz, Michael T.;Gaetz, William C.;Cheyne, Douglas
通讯作者：
Cheyne, Douglas
影响因子：
3.3
作者：
Caspary, DM;Holder, TM;Naritoku, DK
通讯作者：
Naritoku, DK
DOI：
10.1073/pnas.0900728106
发表时间：
2009-05-19
影响因子：
11.1
作者：
Muthukumaraswamy, Suresh D.;Edden, Richard A. E.;Singh, Krish D.
通讯作者：
Singh, Krish D.