Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Maternal and Cord Blood Erythrocytes
Superoxide Dismutase, Catalase and Glutathione Peroxidase Activities in Maternal and Cord Blood Erythrocytes
复制标题
母体和脐带血红细胞中的超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性
DOI：
10.1515/cclm.1980.18.11.771
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
F. Bombelli
中科院分区：
文献类型：
--
作者：
A. Agostoni;G. Gerli;L. Beretta;M. Bianchi;M. Vignali;F. Bombelli
“抗氧化”酶超氧化物歧化酶，过氧化氢酶和谷胱甘肽过氧化物酶进行了测定，在一个生物模型与低氧张力（红细胞从脐带血的新生儿）。新生儿红细胞过氧化氢酶和谷胱甘肽过氧化物酶活性显着低于他们的母亲和正常对照组。与此相反，超氧化物歧化酶活性不变。因此，超氧化物歧化酶的正常活动似乎是必要的，以保护红细胞免受超氧化物自由基在胎儿的生活，而即使是低活性的过氧化氢酶和谷胱甘肽过氧化物酶足以保护红细胞免受过氧化氢。在新生儿出生后的第一天，脐带血红细胞中存在的“抗氧化”酶活性与胆红素浓度之间没有相关性。
The "antioxidant" enzymes superoxide dismutase, catalase and glutathione peroxidase were assayed in a biological model with low oxygen tension (red cells from cord blood of newborn infants). Catalase and glutathione peroxidase activities in red cells of newborns were significantly lower when compared with their mothers and with normal controls. In contrast, superoxide dismutase activity was unchanged. Thus, normal activities of superoxide dismutase seem to be necessary in order to protect red blood cells from superoxide radicals during foetal life, while even low activities of catalase and glutathione peroxidase are sufficient to protect red blood cells from hydrogen peroxide. No correlation was found between the "antioxidant" enzyme activities present in cord blood erythrocytes and the bilirubin concentrations during the first days of life.