Energy homeostasis, obesity and eating disorders: Recent advances in endocrinology
Energy homeostasis, obesity and eating disorders: Recent advances in endocrinology
复制标题
DOI：
10.1093/jn/134.2.295
复制
发表时间：
2004-02-01
影响因子：
4.2
通讯作者：
Mantzoros, CS
中科院分区：
文献类型：
--
作者：
Gale, SM;Castracane, VD;Mantzoros, CS
肥胖导致的健康问题可能会抵消现代医学最近取得的许多健康成果，肥胖症可能会取代烟草成为发达国家的头号健康风险。据估计，每年有300 000人死亡和严重发病率可直接归因于肥胖，主要原因是心脏病、糖尿病、癌症、哮喘、睡眠呼吸暂停、关节炎、生殖并发症和心理障碍。在肥胖日益普遍的同时，关于能量平衡控制和肥胖发病机制的科学和临床研究也急剧增加，以加深我们对能量平衡的理解。现在已经认识到，有许多中枢和外周因素参与了能量稳态，对这些机制的了解有望导致有效的肥胖控制治疗。这篇简短的综述讨论了最近发现的几个分子通路在能量稳态、肥胖和饮食失调控制中的潜在作用。
Health problems resulting from obesity could offset many of the recent health gains achieved by modern medicine, and obesity may replace tobacco as the number one health risk for developed societies. An estimated 300,000 deaths per year and significant morbidity are directly attributable to obesity, mainly due to heart disease, diabetes, cancer, asthma, sleep apnea, arthritis, reproductive complications and psychological disturbances. In parallel with the increasing prevalence of obesity, there has been a dramatic increase in the number of scientific and clinical studies on the control of energy homeostasis and the pathogenesis of obesity to further our understanding of energy balance. It is now recognized that there are many central and peripheral factors involved in energy homeostasis, and it is expected that the understanding of these mechanisms should lead to effective treatments for the control of obesity. This brief review discusses the potential role of several recently discovered molecular pathways involved in the control of energy homeostasis, obesity and eating disorders.