A Drosophila mechanosensory transduction channel
A Drosophila mechanosensory transduction channel
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DOI：
10.1126/science.287.5461.2229
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发表时间：
2000-03-24
期刊：
影响因子：
56.9
通讯作者：
Zuker, CS
中科院分区：
文献类型：
--
作者：
Walker, RG;Willingham, AT;Zuker, CS
机械感觉转导涉及多种感官，包括本体感觉、触觉、平衡和听觉。这些感觉的关键元素是一个机械门控离子通道，它将声音、压力或运动转化为特殊感觉细胞兴奋性的变化。尽管机械感觉系统很普遍，但人们对转导通道的分子性质知之甚少。为了确定这样的通道，我们分析了果蝇机械感受突变体的机械感觉生理缺陷，NO机械感受器潜力C(OnompC)基因功能丧失突变实际上取消了机械感觉信号。NompC编码一种新的离子通道，它是机械感觉转导所必需的。与预期的转导通道一样，D、黑素胃丝虫NOMPC和秀丽线虫的同源物在机械感觉器官中选择性地表达。
Mechanosensory transduction underlies a wide range of senses, including proprioception, touch, balance, and hearing. The pivotal element of these senses is a mechanically gated ion channel that transduces sound, pressure, or movement into changes in excitability of specialized sensory cells. Despite the prevalence of mechanosensory systems, Little is known about the molecular nature of the transduction channels. To identify such a channel, we analyzed Drosophila melanogaster mechanoreceptive mutants for defects in mechanosensory physiology, Loss-of-function mutations in the no mechanoreceptor potential C (nompC) gene virtually abolished mechanosensory signaling. nompC encodes a new ion channel that is essential for mechanosensory transduction. As expected for a transduction channel, D, melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanosensory organs.