An analysis of true- and false-positive results of vocal fold uptake in positron emission tomography-computed tomography imaging
An analysis of true- and false-positive results of vocal fold uptake in positron emission tomography-computed tomography imaging
复制标题
DOI：
10.1017/s002221511700247x
复制
发表时间：
2017-12
期刊：
影响因子：
--
通讯作者：
N. Seymour;G. Burkill;M. Harries
中科院分区：
文献类型：
--
作者：
N. Seymour;G. Burkill;M. Harries
摘要目的：正电子发射断层扫描-18氟脱氧葡萄糖计算机断层扫描在头颈部肿瘤的研究中具有重要作用。氟-18氟脱氧-D-葡萄糖不是肿瘤特异性示踪剂，也可以在良性病变中积聚。因此，正电子发射断层扫描-计算机断层扫描解释困难在头颈部很常见，可能会产生假阳性结果。本研究旨在调查经氟-18氟脱氧葡萄糖正电子发射断层扫描-计算机断层扫描发现声带摄取异常的患者。方法：正电子发射断层扫描-计算机断层扫描在15个月的时间内被确定，其中报告包含单侧声带摄取或声带病理的证据。对患者笔记和喉镜检查结果进行分析。结果：46例患者经正电子发射计算机体层摄影确诊为声带异常摄取。23名患者接受了正电子发射断层扫描-计算机断层扫描和柔性喉镜检查：61%的患者正电子发射断层扫描-计算机断层扫描为真阳性，39%的患者扫描结果为假阳性。结论：大多数患者因正电子发射断层扫描发现异常而转至耳鼻咽喉科就诊，其结果为真阳性。不对称的氟-18氟脱氧-D-葡萄糖摄取应该引起声带病理的怀疑，接受大约40%的假阳性率。
Abstract Objectives: Positron emission tomography-computed tomography with fluorine-18 fluorodeoxy-D-glucose has a major role in the investigation of head and neck cancers. Fluorine-18 fluorodeoxy-D-glucose is not a tumour-specific tracer and can also accumulate in benign pathology. Therefore, positron emission tomography-computed tomography scan interpretation difficulties are common in the head and neck, which can produce false-positive results. This study aimed to investigate patients detected as having abnormal vocal fold uptake on fluorine-18 fluorodeoxy-D-glucose positron emission tomography-computed tomography. Methods: Positron emission tomography-computed tomography scans were identified over a 15-month period where reports contained evidence of unilateral vocal fold uptake or vocal fold pathology. Patients’ notes and laryngoscopy results were analysed. Results: Forty-six patients were identified as having abnormal vocal fold uptake on positron emission tomography-computed tomography. Twenty-three patients underwent positron emission tomography-computed tomography and flexible laryngoscopy: 61 per cent of patients had true-positive positron emission tomography-computed tomography scans and 39 per cent had false-positive scan results. Conclusion: Most patients referred to ENT for abnormal findings on positron emission tomography-computed tomography scans had true-positive findings. Asymmetrical fluorine-18 fluorodeoxy-D-glucose uptake should raise suspicion of vocal fold pathology, accepting a false-positive rate of approximately 40 per cent.