Intrathecal morphine, but not buprenorphine or pentazocine, can induce spastic paraparesis after a noninjurious interval of spinal cord ischemia in the rat
Intrathecal morphine, but not buprenorphine or pentazocine, can induce spastic paraparesis after a noninjurious interval of spinal cord ischemia in the rat
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DOI：
10.1213/01.ane.0000133915.56613.d9
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发表时间：
2004-11-01
影响因子：
5.7
通讯作者：
Miyata, Y
中科院分区：
文献类型：
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作者：
Nakamura, S;Kakinohana, M;Miyata, Y
在这项研究中，我们试图确定鞘内注射（IT）喷他佐辛或丁丙诺啡对大鼠脊髓缺血后神经功能的影响。虽然IT吗啡（30微克）诱导痉挛性下肢轻瘫后6分钟的主动脉闭塞，喷他佐辛（150微克）或丁丙诺啡（4微克）产生神经功能障碍。我们的研究结果表明，各种阿片类药物对脊髓缺血后运动功能的影响是阿片类药物特异性的。
In this study, we sought to determine the effect of intrathecal (IT) pentazocine or buprenorphine on the neurological outcome after a short interval of spinal cord ischemia in rats. Although IT morphine (30 mug) induced spastic paraparesis after 6 min of aortic occlusion, neither pentazocine (150 mug) nor buprenorphine (4 mug) produced neurological dysfunction. Our results indicate that the effect of various opioids on the motor function after a noninjurious interval of spinal cord ischemia is opioid-specific.