Microperimetry of localized retinal nerve fiber layer defects
Microperimetry of localized retinal nerve fiber layer defects
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DOI：
10.1016/s0042-6989(97)00171-5
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发表时间：
1998-03-01
期刊：
影响因子：
1.8
通讯作者：
Rosetti, L
中科院分区：
文献类型：
--
作者：
Orzalesi, N;Miglior, S;Rosetti, L
本研究的目的是确定涉及局部视网膜神经纤维层（RNFL）缺陷的视网膜区域的敏感性，并评估微视野和标准全阈值中心30度视野测试之间的相关性。25例局灶性RNFL缺损的患者，通过氩蓝扫描激光检眼镜（SLO）进行评估，接受自动30度中心视野检查和SLO微视野检查。微视野检查根据标准程序（红外激光眼底成像; HeNe激光10 candles/m2背景照明，固定辅助和刺激产生;手动眼底跟踪）进行。刺激的大小为Goldmann III，持续时间为0.1秒。在局灶性RNFL缺损眼中，12例出现5dB以上的深暗点，13例出现1- 4dB的浅暗点。暗点主要分布于缺损的整个范围或集中于缺损的颞侧或鼻侧，边界清晰。与自动视野检查，暗点，定义为至少10 dB的单点凹陷或至少5 dB的凹陷，在两个或两个以上的连续点对应的RNFL缺陷，发现只有14的25眼微视野缺损。局灶性RNFL缺陷对应于通过微视野检查评估的视网膜敏感性降低的局部区域。结构和微视野检查结果之间的密切对应关系表明，在高血压眼中，局部RNFL缺陷对应于视觉功能障碍，可能与神经节细胞的大量萎缩有关。(C)1998爱思唯尔科技有限公司版权所有。
The aim of this study was to determine the sensitivity of retinal areas involved in a localized retinal nerve fiber layer (RNFL) defect and to assess correlations between microperimetry and the standard full threshold central 30 deg visual field test. Twenty-five patients with focal RNFL defects, evaluated by means of Argon-blue scanning laser ophthalmoscopy (SLO), underwent an automated 30 deg central visual field examination and a microperimetry with SLO, Microperimetry was performed according to standard procedures (infrared laser for fundus imaging; HeNe laser for 10 candles/m(2) background illumination, fixation aid and generation of stimuli; manual fundus tracking). The size of stimuli was Goldmann III with 0.1 sec duration. In eyes with focal RNFL defects a deep microperimetric scotoma of at least 5 dB was found in 12 cases and a mild scotoma (1-4 dB) in 13 cases, These scotomas were mainly located throughout the whole defect or grouped in the temporal or nasal sides of the defect and were characterized by sharp and well-defined borders. With automated perimetry, a scotoma, defined by a single point depression of at least 10 dB or a depression of at least 5 dB in two or more contiguous points corresponding to the RNFL defect, was found in only 14 out of 25 eyes with microperimetric defect. Focal RNFL defects correspond to localized areas of depressed retinal sensitivity as evaluated by microperimetry. The close correspondence between structural and microperimetric findings suggests that, in hypertensive eyes also, localized RNFL defects correspond to visual dysfunction possibly associated with substantial atrophy of ganglion cells. (C) 1998 Elsevier Science Ltd. All rights reserved.