Suppression of antibody‐mediated arthritis in mice by Fab fragments of the mediating antibodies
Suppression of antibody‐mediated arthritis in mice by Fab fragments of the mediating antibodies
复制标题
通过介导抗体的 Fab 片段抑制小鼠抗体介导的关节炎
DOI：
10.1111/j.1476-5381.2010.00938.x
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发表时间：
2010
影响因子：
7.3
通讯作者：
H. Kuramoto
中科院分区：
文献类型：
--
作者：
S. Yoshino;M. Sasahara;P. Hutamekalin;K. Yamaki;N. Mizutani;H. Kuramoto
抗体的Fab片段（Fab）保持结合特异性抗原的能力，但缺乏补体的结合位点以及与效应细胞（例如在炎症中起重要作用的巨噬细胞）上的受体结合的位点。在本研究中，我们研究了卵清蛋白（OVA）特异性Fab是否能够特异性抑制小鼠抗OVA抗体介导的关节炎（AOA-MA）。
BACKGROUND AND PURPOSE Fab fragments (Fabs) of antibodies maintain the ability to bind specific antigens, but lack the binding site for complement as well as the site for binding to receptors on effector cells, such as macrophages that play an important role in inflammation. In the present study, we investigated whether Fabs specific for ovalbumin (OVA) were specifically able to suppress anti‐OVA antibody‐mediated arthritis (AOA‐MA) in mice.