Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression

Discovery of endocannabinoids and some random thoughts on their possible roles in neuroprotection and aggression
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DOI:
10.1054/plef.2001.0340
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发表时间:
2002-02-01
影响因子:
3
通讯作者:
Mechoulam, R
Mechoulam, R
中科院分区:
医学4区
文献类型:
--
作者:
Mechoulam, R

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A short history of the discovery of the main plant cannabinoid, Delta9-tetrahydrocannabinol and of the endogenous cannabinoids anandamide, 2-arachidonoyl glycerol and 2-arachidonyl glyceryl ether (noladin ether) is presented. The role of the cannabinoids in neuroprotection, with emphasis on the endocannabinoids, is described. The unexpected production of aggression by Cannabis and cannabinoids under stressful conditions, published mainly in the past, is summarized. (C) 2002 Elsevier Science Ltd. All rights reserved.