Dietary intake of heterocyclic amines and benzo(a)pyrene: Associations with pancreatic cancer
Dietary intake of heterocyclic amines and benzo(a)pyrene: Associations with pancreatic cancer
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DOI：
10.1158/1055-9965.epi-04-0514
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发表时间：
2005-09-01
影响因子：
3.8
通讯作者：
Sinha, R
中科院分区：
文献类型：
--
作者：
Anderson, KE;Kadlubar, FF;Sinha, R
目的：杂环胺(HCA)和多环芳烃是肉类烹调过程中随时间和温度变化形成的致癌物和致突变物。在一项以人群为基础的病例对照研究中，我们试图评估膳食摄入六氯环己烷和苯并(A)芘[B(A)PI]与外分泌性胰腺癌之间的关系。方法：受试者(193例患者和674名对照)提供了他们通常的肉类摄入量和准备方法的信息，如炖肉、油炸或烤/烧烤等。我们使用肉类来源的HCA、B(A)P和诱变剂数据库和问卷调查来估计PhIP、DiMeIQx、MelQx、B(A)P的摄入量和诱变活性(每日肉类摄入量的回复变种/克)。结果：在调整了年龄、性别、吸烟、教育程度、种族和糖尿病的分析中，最高和最低五分位数的优势比和95%可信区间分别为：PhIP，1.8(1.0-3.1)；DiMeIQx，2.0(1.2-3.5)；MeIQx，1.5(0.9-2.7)；13(A)P，2.2(1.2-4.0)；和致突变活性，2.4(1.3-4.3)。结论：烤肉和煎肉中的HCAs和B(A)P可能与胰腺癌的风险增加有关。
Objective: Heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons, formed in temperature- and time-dependent manners during the cooking of meat, are mutagens and carcinogens. We sought to assess the association between dietary intake of HCA and benzo(a)pyrene [B(a)PI and exocrine pancreatic cancer in a population-based case-control study.Methods: Subjects (193 cases and 674 controls) provided information on their usual meat intake and preparation method, e.g., stewed, fried, or grilled/barbecued, etc. Meat doneness preferences were measured using photographs that showed internal doneness and external brownness. We used a meat-derived HCA, B(a)P, and mutagen database with a questionnaire to estimate intake of PhIP, DiMeIQx, MelQx, B(a)P, and mutagenic activity (revertants/g of daily meat intake). Data were analyzed with unconditional logistic regression.Results: In analyses adjusted for age, sex, smoking, education, race, and diabetes, the odds ratio and 95% confidence interval for the highest compared with the lowest quintile were as follows: PhIP, 1.8 (1.0-3.1); DiMeIQx, 2.0 (1.2-3.5); MeIQx, 1.5 (0.9-2.7); 13(a)P, 2.2 (1.2-4.0); and mutagenic activity, 2.4 (1.3-4.3).Conclusions: HCAs and B(a)P from well-done barbecued and pan-fried meats may be associated with increased risk for pancreatic cancer.