Selective Phosphorylation of Akt/Protein-Kinase B Isoforms in Response to Dietary Cues
Selective Phosphorylation of Akt/Protein-Kinase B Isoforms in Response to Dietary Cues
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DOI：
10.3389/fcell.2019.00206
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发表时间：
2019-10
影响因子：
5.5
通讯作者：
L. Trautenberg;E. Prince;Cornelia Maas;Nora Beier;Freya Honold;M. Grzybek;M. Brankatschk
中科院分区：
文献类型：
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作者：
L. Trautenberg;E. Prince;Cornelia Maas;Nora Beier;Freya Honold;M. Grzybek;M. Brankatschk
高热量饮食是代谢综合征在西方社会持续蔓延的原因之一。智能食品设计是预防代谢应激的有力工具，寻找合适的生物活性添加剂是一项持续的任务。营养感应胰岛素途径是一种进化保守机制，在代谢、生长和发育中发挥重要作用。最近，发现了能够刺激胰岛素信号传导的脂质信号。然而，迄今为止，它们活动的机制基础仍然不清楚。我们发现特定的 Akt/蛋白激酶 B 亚型对不同的富含热量的饮食有反应，并增强细胞胰岛素级联的活性。我们的数据为现有模型增加了一个新的维度，并将果蝇定位为研究饮食脂质线索与胰岛素诱导的细胞信号通路之间关系的强大工具。
A calorie-rich diet is one reason for the continuous spread of metabolic syndromes in western societies. Smart food design is one powerful tool to prevent metabolic stress, and the search for suitable bioactive additives is a continuous task. The nutrient-sensing insulin pathway is an evolutionary conserved mechanism that plays an important role in metabolism, growth and development. Recently, lipid cues capable to stimulate insulin signaling were identified. However, the mechanistic base of their activity remains obscure to date. We show that specific Akt/Protein-kinase B isoforms are responsive to different calorie-rich diets, and potentiate the activity of the cellular insulin cascade. Our data add a new dimension to existing models and position Drosophila as a powerful tool to study the relation between dietary lipid cues and the insulin-induced cellular signal pathway.