URINARY-EXCRETION OF PGI2/3-M AND RECENT N-6/3 FATTY-ACID INTAKE
URINARY-EXCRETION OF PGI2/3-M AND RECENT N-6/3 FATTY-ACID INTAKE
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DOI：
10.1016/0090-6980(89)90092-0
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发表时间：
1989-04-01
影响因子：
2.9
通讯作者：
KUWAMORI, T
中科院分区：
文献类型：
--
作者：
HAMAZAKI, T;FISCHER, S;KUWAMORI, T
流行病学研究进行了日本渔村时，鱼的渔获量最高，在日本的农业村庄与通常的鱼消费。摄入的二十碳五烯酸，二十二碳六烯酸和花生四烯酸显着高于渔村在3天的研究比在农业村。收集尿当天的二十碳五烯酸摄入量和Δ E排泄量之间的相关性。17- 2，3-二去甲-6-酮-前列腺素F1 α，前列腺素I3的主要尿代谢物，是非常显著的，而花生四烯酸或亚油酸的摄入与2，3-二去甲-6-酮-前列腺素F1 α的排泄之间没有相关性，前列腺素I2的主要尿代谢产物。我们认为，花生四烯酸池前列腺素I2的生产不会很快受到饮食中的亚油酸或花生四烯酸，因为一个大池大小的花生四烯酸和缓慢的酸转化为花生四烯酸亚油酸，而前列腺素I3的形成是直接相关的二十碳五烯酸的摄入量。
Epidemiological studies were performed in a Japanese fishing village when catches of fish were highest and in Japanese farming village with usual fish consumption. Intake of eicosapentaenoic, docosahexaenoic and also arachidonic acid were significantly higher in the fishing village during the 3 days of the study than in the farming village. The correlation between eicosapentaenoic acid intake on the day when urine was collected and excretion of .DELTA. 17-2,3-dinor-6-keto-prostaglandin F1.alpha., the main urinary metabolite of prostaglandin I3, was highly significant whereas there was no correlation between arachidonic or linoleic acid intake and excretion of 2,3-dinor-6-keto-prostaglandin F1.alpha., the main urinary metabolite of prostaglandin I2. We suggest that the arachidonic acid pool for prostaglandin I2 production is not quickly influenced by dietary linoleic or arachidonic acid because of a large pool size of arachidonic acid and a slow conversion of acid to arachidonic linoleic acid, while prostaglandin I3 formation is directly related to the intake of eicosapentaenoic acid.