Mortality associated with proton pump inhibitors in cirrhotic patients with spontaneous bacterial peritonitis
Mortality associated with proton pump inhibitors in cirrhotic patients with spontaneous bacterial peritonitis
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DOI：
10.1111/jgh.12426
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发表时间：
2014-04-01
影响因子：
4.1
通讯作者：
Jung, Hyun Chae
中科院分区：
文献类型：
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作者：
Kwon, Jee Hye;Koh, Seong-Joon;Jung, Hyun Chae
背景与目的本研究旨在探讨抑酸治疗是否会增加自发性细菌性腹膜炎(SBP)的风险，并确定与自发性细菌性腹膜炎(SBP)患者死亡率相关的因素。根据有无SBP将患者分为两组。分析与SBP发生相关的因素。结果共纳入1140例患者(中位年龄62岁；男性75%；终末期肝病模型评分17分)。533名患者被确认患有自闭性腹痛。在Logistic回归分析中，组胺-2受体拮抗剂的使用、质子泵抑制剂(PPI)的使用、高入院MELD评分和高龄与SBP的发生有关。在30天内使用PPI(调整后的优势比[AOR]1.960；95%可信区间[CI]1.190~3.227；P=0.008)，入院MELD评分较高(调整后的优势比1.054；95%CI 1.032~1.076；P
Background and AimThe aims of this study were to investigate whether acid suppressive therapy increases the risk of spontaneous bacterial peritonitis (SBP) and to define factors associated with mortality in cirrhotic patients with SBP.MethodsCirrhotic patients who had undergone paracentesis after hospitalization were included. Those patients were divided into two groups according to the presence or absence of SBP. Factors associated with the development of SBP were analyzed. Mortality rates during hospitalization or within 30 days after SBP and the factors associated with mortality were also analyzed.ResultsA total of 1140 patients (median age, 62; men, 75%; model for end-stage liver disease [MELD] score, 17) were included. Five hundred thirty-three patients were identified as having SBP. In the logistic regression, the use of histamine-2 receptor antagonists, the use of proton pump inhibitors (PPIs), a high admission MELD score, and old age were associated with the development of SBP. The use of PPIs within 30 days (adjusted odds ratio [aOR] 1.960; 95% confidence interval [CI] 1.190-3.227; P=0.008), a higher admission MELD score (aOR 1.054; 95% CI 1.032-1.076; P