State of molecular motion of cholesterol in lecithin bilayers
State of molecular motion of cholesterol in lecithin bilayers
复制标题
卵磷脂双层中胆固醇的分子运动状态
作者：
P. Kroon;M. Kainosho;S. Chan
胆固醇是许多生物膜的主要成分。尽管它的确切功能还不完全清楚，但大量研究表明，无论是在模型中还是在生物膜中，胆固醇都可以影响脂类碳氢链的堆积。这种相互作用被认为是这样的：在热相变温度(TC)以上，胆固醇抑制碳氢链的弯曲，而在TC以下，它阻止碳氢链结晶成刚性αGel2-6。
CHOLESTEROL is a major constituent of many biological membranes. Although its exact function is not completely understood, a large number of studies have indicated that cholesterol can affect the packing of lipid hydrocarbon chains, both in model and in biological membranes1. The interaction is envisaged to be such that above the thermal phase transition temperature (Tc), cholesterol inhibits flexing of the hydrocarbon chains, whereas below Tc it prevents the chains from crystallising into the rigid α gel2–6.