Correlation between recent thymic emigrants and CD31+ (PECAM-1) CD4+ T cells in normal individuals during aging and in lymphopenic children
Correlation between recent thymic emigrants and CD31+ (PECAM-1) CD4+ T cells in normal individuals during aging and in lymphopenic children
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DOI：
10.1002/eji.200636976
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发表时间：
2007-11-01
影响因子：
5.4
通讯作者：
Guengoer, Tayfun
中科院分区：
文献类型：
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作者：
Junge, Sonja;Kloeckener-Gruissem, Barbara;Guengoer, Tayfun
CD31(+)CD45RA(+)RC（-）淋巴细胞含有大量携带TREC的T细胞；然而，在衰老和淋巴细胞减少的情况下，CD31(+)CD4（+）淋巴细胞与TREC之间的相关性尚未得到充分的研究。我们分析了健康个体从出生到老年的CD31（+）和CD31(-) CD4（+）淋巴细胞的TREC、端粒长度和端粒酶活性。分类后的CD31(+)CD45RA(+)RO（-）初始CD4+淋巴细胞含有高TREC数量，而CD31(+)CD45RA(-)RO（+）细胞(包括
CD31(+)CD45RA(+)RC(-) lymphocytes contain high numbers of T cell receptor circle (TREC)-bearing T cells; however, the correlation between CD31(+)CD4(+) lymphocytes and TREC during aging and under lymphopenic conditions has not yet been sufficiently investigated. We analyzed TREC, telomere length and telomerase activity within sorted CD31(+) and CD31(-) CD4(+) lymphocytes in healthy individuals from birth to old age. Sorted CD31(+)CD45RA(+)RO(-) naive CD4+ lymphocytes contained high TREC numbers, whereas CD31(+)CD45RA(-)RO(+) cells (comprising