Simultaneous transcranial direct current stimulation (tDCS) and whole-head magnetoencephalography (MEG): assessing the impact of tDCS on slow cortical magnetic fields
Simultaneous transcranial direct current stimulation (tDCS) and whole-head magnetoencephalography (MEG): assessing the impact of tDCS on slow cortical magnetic fields
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DOI：
10.1016/j.neuroimage.2015.09.068
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发表时间：
2016-10-01
期刊：
影响因子：
5.7
通讯作者：
Soekadar, Surjo R.
中科院分区：
文献类型：
--
作者：
Garcia-Cossio, Eliana;Witkowski, Matthias;Soekadar, Surjo R.
经颅直流电刺激（tDCS）可以影响认知、情感或运动脑功能。尽管先前的成像研究表明tDCS对脑代谢有广泛的影响，但由于在tDCS期间难以同时记录这些活动，因此无法证实tDCS对任务相关脑区域的电或磁源活动的直接影响。本研究的目的是为了证明在tDCS期间全头部神经磁源定位和脑活动重建的可行性，并确认tDCS对任务相关脑区正在进行的神经磁活动的直接影响。在这里，我们首次表明tDCS对任务相关区域的慢皮层磁场（SCF, 0-4 Hz）有直接影响，这些区域与先前在代谢神经成像研究中描述的大脑区域相同。14名健康志愿者进行选择反应时间（RT）任务，同时记录全头脑磁图（MEG）。在没有刺激的情况下，使用合成孔径磁强计（SAM）计算scf的任务相关源活性，同时在右侧初级运动皮层（M1）上传递阳极、阴极或假性tDCS。源重建揭示了大脑区域中与任务相关的SCF调节，与先前的代谢神经成像研究精确匹配。阳极和阴极tDCS对初级感觉运动皮层和内侧中央-顶叶皮层的RT和SCF有极性依赖的影响。结合tDCS和全头部脑磁图是研究经颅电流对持续的神经磁源活动、脑功能和行为的直接影响的有力方法。(C) 2015爱思唯尔公司版权所有。
Transcranial direct current stimulation (tDCS) can influence cognitive, affective or motor brain functions. Whereas previous imaging studies demonstrated widespread tDCS effects on brain metabolism, direct impact of tDCS on electric or magnetic source activity in task-related brain areas could not be confirmed due to the difficulty to record such activity simultaneously during tDCS. The aim of this proof-of-principal study was to demonstrate the feasibility of whole-head source localization and reconstruction of neuromagnetic brain activity during tDCS and to confirm the direct effect of tDCS on ongoing neuromagnetic activity in task-related brain areas. Here we show for the first time that tDCS has an immediate impact on slow cortical magnetic fields (SCF, 0-4 Hz) of task-related areas that are identical with brain regions previously described in metabolic neuroimaging studies. 14 healthy volunteers performed a choice reaction time (RT) task while whole-head magnetoencephalography (MEG) was recorded. Task-related source-activity of SCFs was calculated using synthetic aperture magnetometry (SAM) in absence of stimulation and while anodal, cathodal or sham tDCS was delivered over the right primary motor cortex (M1). Source reconstruction revealed task-related SCF modulations in brain regions that precisely matched prior metabolic neuroimaging studies. Anodal and cathodal tDCS had a polarity-dependent impact on RT and SCF in primary sensorimotor and medial centro-parietal cortices. Combining tDCS and whole-head MEG is a powerful approach to investigate the direct effects of transcranial electric currents on ongoing neuromagnetic source activity, brain function and behavior. (C) 2015 Elsevier Inc. All rights reserved.