Biaxial rupture properties of ascending thoracic aortic aneurysms
Biaxial rupture properties of ascending thoracic aortic aneurysms
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DOI：
10.1016/j.actbio.2016.06.028
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发表时间：
2016-09-15
影响因子：
9.7
通讯作者：
Avril, Stephane
中科院分区：
文献类型：
--
作者：
Duprey, Ambroise;Trabelsi, Olfa;Avril, Stephane
尽管已经对从接受择期手术修复的患者的胸升主动脉瘤（ATAA）中获得的数百个样本进行了生物力学表征，但其破裂特性始终来自单轴拉伸试验。由于其凸起形状，ATAA在体内被双轴拉伸。为了了解ATAA的双轴断裂，我们的小组开发了一种新的方法，基于膨胀和全场光学测量。本文件有三个目标。首先，我们将审查31例患者的队列通过膨胀膨胀试验获得的失效特性（最大应力，最大拉伸），并将其与先前发表的研究中通过单轴拉伸获得的失效特性进行比较。其次，我们将研究失效特性与患者年龄之间的关系，表明55岁以下的患者显示出明显更高的强度。第三，我们将基于组织的可延展性来定义破裂风险，并且我们将表明这种破裂风险与组织的生理弹性模量密切相关，而与患者的年龄、ATAA直径或主动脉瓣表型无关。文献中不存在承受双轴张力的胸升主动脉瘤（ATAA）的破裂特性。为了解决这一问题，我们的团队开发了一种基于膨胀膨胀和全场光学测量的新方法。在这里，我们报告了31例患者使用这种方法获得的破裂特性。它示出的第一次，发生破裂时，施加到ATAA的拉伸达到最大的组织的可延伸性，并且该最大的可延伸性与弹性性能强烈相关。结果是更好地检测有风险的个体进行择期手术修复。(C)2016 Acta Materialia Inc.由爱思唯尔有限公司出版。保留所有权利。
Although hundreds of samples obtained from ascending thoracic aortic aneurysms (ATAA) of patients undergoing elective surgical repair have already been characterized biomechanically, their rupture properties were always derived from uniaxial tensile tests. Due to their bulge shape, ATAAs are stretched biaxially in vivo. In order to understand the biaxial rupture of ATAAs, our group developed a novel methodology based on bulge inflation and full-field optical measurements. The objective of the current paper is threefold. Firstly, we will review the failure properties (maximum stress, maximum stretch) obtained by bulge inflation testing on a cohort of 31 patients and compare them with failure properties obtained by uniaxial tension in a previously published study. Secondly, we will investigate the relationship between the failure properties and the age of patients, showing that patients below 55 years of age display significantly higher strength. Thirdly, we will define a rupture risk based on the extensibility of the tissue and we will show that this rupture risk is strongly correlated with the physiological elastic modulus of the tissue independently of the age, ATAA diameter or the aortic valve phenotype of the patient.Statement of SignificanceDespite their medical importance, rupture properties of ascending thoracic aortic aneurysms (ATAA) subjected to biaxial tension were inexistent in the literature. In order to address this lack, our group developed a novel methodology based on bulge inflation and full-field optical measurements. Here we report rupture properties obtained with this methodology on 31 patients. It is shown for the first time that rupture occurs when the stretch applied to ATAAs reaches the maximum extensibility of the tissue and that this maximum extensibility correlates strongly with the elastic properties. The outcome is a better detection of at-risk individuals for elective surgical repair. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.