Burden of interpandemic influenza in children younger than 5 years: A 25-year prospective study
Burden of interpandemic influenza in children younger than 5 years: A 25-year prospective study
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DOI：
10.1086/338363
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发表时间：
2002-01-15
影响因子：
6.4
通讯作者：
Wright, PF
中科院分区：
文献类型：
--
作者：
Neuzil, KM;Zhu, YW;Wright, PF
许多呼吸道病毒会导致幼儿发病，但只有流感病毒才能获得许可的疫苗和有效的口服疗法。为了确定实验室确认的流感疾病的发病率，我们前瞻性地跟踪了从1974年到1999年在范德比尔特疫苗诊所登记的1665名5岁健康儿童。病毒培养是在儿童出现临床疾病时获得的。流感病毒的分离与每年每1000名儿童中估计有95次有流感症状的儿童就诊、46次急性中耳炎和8次下呼吸道疾病有关。急性中耳炎和下呼吸道疾病的发病率在年龄段儿童中最高，
Many respiratory viruses cause morbidity in young children, but a licensed vaccine and effective oral therapy are available only for influenzavirus. To determine the incidence of laboratory-confirmed influenza illness, we prospectively followed up 1665 healthy children aged, 5 years who were enrolled in the Vanderbilt Vaccine Clinic at some point from 1974 through 1999. Viral cultures were obtained when the children presented with clinical illness. The isolation of influenzavirus was associated with an estimated 95 health care visits for children with symptoms of influenza, 46 episodes of acute otitis media, and 8 episodes of lower respiratory tract disease per 1000 children yearly. Rates of acute otitis media and lower respiratory tract disease were highest among children aged,