N-Heterocyclic dicarboxylic acids: Broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria
N-Heterocyclic dicarboxylic acids: Broad-spectrum inhibitors of metallo-β-lactamases with co-antibacterial effect against antibiotic-resistant bacteria
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DOI：
10.1016/j.bmcl.2012.06.074
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发表时间：
2012-08-15
影响因子：
2.7
通讯作者：
Crowder, Michael W.
中科院分区：
文献类型：
--
作者：
Feng, Lei;Yang, Ke-Wu;Crowder, Michael W.
为了鉴定针对金属β-内酰胺酶（M β Ls）的新型广谱抑制剂，测试了几种N-杂环衍生物作为M β Ls CcrA、ImiS和L1的抑制剂，这些酶是来自不同M β L亚类的代表性酶。三种N-杂环二羧酸衍生物对CcrA和L1具有竞争性抑制作用，
In an effort to identify novel, broad-spectrum inhibitors against the metallo-beta-lactamases (M beta Ls), several N-heterocyclic derivatives were tested as inhibitors of M beta Ls CcrA, ImiS, and L1, which are representative enzymes from the distinct M beta L subclasses. Three N-heterocyclic dicarboxylic acid derivatives were competitive inhibitors of CcrA and L1, exhibiting K-i values