Health-related quality of life and symptoms of depression in extremely obese persons seeking bariatric surgery
Health-related quality of life and symptoms of depression in extremely obese persons seeking bariatric surgery
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DOI：
10.1381/0960892053576578
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发表时间：
2005-03-01
期刊：
影响因子：
2.9
通讯作者：
Faith, MS
中科院分区：
文献类型：
--
作者：
Fabricatore, AN;Wadden, TA;Faith, MS
背景资料：极度肥胖，定义为体重指数（BMI）≥ 40 kg/m2，与抑郁风险增加和健康相关生活质量（HRQoL）受损相关。方法：研究对象为306名接受减肥手术的患者（平均年龄43.8 ± 9.4岁，体重指数52.8 ± 9.3 kg/m2），他们在手术前完成了问卷调查以评估抑郁症状和HRQoL。我们将HRQoL损伤定义为低于全国平均值的分数>= 1 SD。结果：HRQoL损伤是常见的：>40%的参与者在身体功能、身体角色限制和身体疼痛的受损范围内得分。方差分析（ANOVA）的结果表明，HRQoL的损害显着相关的抑郁症状。HRQoL受损的患者得分高于临床显著抑郁的临界点，而无此类损伤的患者得分低于该临界点，无论BMI如何。BMI对抑郁症的贡献在任何ANOVA中均不显着。结论：HRQoL与抑郁症症状的相关性比BMI更强，更直接。这些研究结果强调了需要评估极端肥胖患者的HRQoL，并表明跨学科的策略，以解决HRQoL损伤可能是有益的，在这一人群。
Background: Extreme obesity, defined by a body mass index (BMI) >= 40 kg/m(2), is associated with increased risk of depression and with impairments in health-related quality of life (HRQoL). This study examined the relationships among BMI, HRQoL, and symptoms of depression in persons with extreme obesity.Method: Participants were 306 patients who sought bariatric surgery (mean +/- SD age 43.8 +/- 9.4 years, BMI 52.8 +/- 9.3 kg/m(2)) and who completed questionnaires to assess symptoms of depression and HRQoL prior to surgery. We defined HRQoL impairment as a score >= 1 SD below national means.Results: Impairments in HRQoL were common: >40% of participants scored in the impaired ranges of physical functioning, physical role limitations, and bodily pain. Results of analyses of variance (ANOVAs) indicated that impairments in HRQoL were significantly related to symptoms of depression. Patients with impaired HRQoL scored above the cut-off point for clinically significant depression, while those without such impairment scored below that cut-off, regardless of BMI. The contribution of BMI to depression was not significant in any ANOVA.Conclusion: HRQoL is more strongly and more directly related to symptoms of depression than is BMI. These findings highlight the need to assess HRQoL in patients with extreme obesity and suggest that interdisciplinary strategies to address HRQoL impairments may be beneficial in this population.