Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
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DOI：
10.1038/85438
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发表时间：
2001-03-01
期刊：
影响因子：
82.9
通讯作者：
Zitvogel, L
中科院分区：
文献类型：
--
作者：
Wolfers, J;Lozier, A;Zitvogel, L
T细胞介导的抗肿瘤免疫反应的启动需要树突状细胞摄取和处理肿瘤抗原，并将其呈递到MHC-I分子上。在这里，我们在一个人体体外模型系统中展示了外体，即由活的肿瘤细胞分泌的一群小的膜泡，含有肿瘤抗原并将其转移到树突状细胞。在小鼠肿瘤外切体摄取后，树突状细胞在同基因和同种异体已建立的小鼠肿瘤中诱导强大的CD8(+)T细胞依赖的抗肿瘤作用。因此，Exosome代表了T细胞交叉激发的肿瘤排斥抗原的新来源，与免疫干预相关。
The initiation of T-cell-mediated antitumor immune responses requires the uptake and processing of tumor antigens by dendritic cells and their presentation on MHC-I molecules. Here we show in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells. After mouse tumor exosome uptake, dendritic cells induce potent CD8(+) T-cell-dependent antitumor effects on syngeneic and allogeneic established mouse tumors. Therefore, exosomes represent a novel source of tumor-rejection antigens for T-cell cross priming, relevant for immunointerventions.