ANTIVIRAL TREATMENT OF ARGENTINE HEMORRHAGIC-FEVER
ANTIVIRAL TREATMENT OF ARGENTINE HEMORRHAGIC-FEVER
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DOI：
10.1016/0166-3542(94)90030-2
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发表时间：
1994-01-01
影响因子：
7.6
通讯作者：
MAIZTEGUI, JI
中科院分区：
文献类型：
--
作者：
ENRIA, DA;MAIZTEGUI, JI
阿根廷出血热是一种由朱宁病毒引起的全身性病毒性疾病，未经治疗的个体死亡率为15-30%。目前的特异性治疗在降低死亡率方面是高度有效的，并且包括以每kg体重的特定剂量的特异性中和抗体早期施用免疫血浆。然而，有几个原因表明需要研究替代疗法。利巴韦林是一种广谱抗病毒剂，可有效治疗其他病毒性出血热，迄今为止对朱宁病毒感染进行的研究表明，这种药物对阿根廷出血热也有有益作用
Argentine hemorrhagic fever is a systemic viral disease caused by Junin virus, with a mortality of 15-30% in untreated individuals. Current specific therapy is highly effective in reducing mortality, and consists of the early administration of immune plasma in defined doses of specific neutralizing antibodies per kg of body weight. However, several reasons suggest the need to investigate alternative therapies. Ribavirin, a broad spectrum antiviral agent, is effective in the treatment of other viral hemorrhagic fevers, and the studies done with Junin virus infections to date indicate that this drug may also have a beneficial effect in Argentine hemorrhagic fever