A laser-driven nanosecond proton source for radiobiological studies
A laser-driven nanosecond proton source for radiobiological studies
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DOI：
10.1063/1.4769372
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发表时间：
2012-12-10
影响因子：
4
通讯作者：
Wilkens, Jan J.
中科院分区：
文献类型：
--
作者：
Bin, Jianhui;Allinger, Klaus;Wilkens, Jan J.
离子束与放射生物学研究和肿瘤治疗有关。与传统的加速器相比，激光驱动离子加速提供了一种潜在的更紧凑和更具成本效益的方式来输送用于放射治疗的离子。在这里，我们表明，通过结合先进的加速使用纳米薄目标和光束传输，真正的纳秒准单能质子束可以产生与桌面激光系统，提供单次剂量高达7戈瑞的活细胞。虽然在他们的婴儿期，激光离子加速器允许研究快速的放射生物学过程，如这里所示的纳秒质子束在人类肿瘤细胞的相对生物学有效性的测量。(C)2012年美国物理学会。[http：//dx.doi.org/10.1063/1.4769372]
Ion beams are relevant for radiobiological studies and for tumor therapy. In contrast to conventional accelerators, laser-driven ion acceleration offers a potentially more compact and cost-effective means of delivering ions for radiotherapy. Here, we show that by combining advanced acceleration using nanometer thin targets and beam transport, truly nanosecond quasi-monoenergetic proton bunches can be generated with a table-top laser system, delivering single shot doses up to 7Gy to living cells. Although in their infancy, laser-ion accelerators allow studying fast radiobiological processes as demonstrated here by measurements of the relative biological effectiveness of nanosecond proton bunches in human tumor cells. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4769372]