Polycyclic aromatic hydrocarbons and cancer in man.
Polycyclic aromatic hydrocarbons and cancer in man.
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DOI：
10.1289/ehp.961041166
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发表时间：
1996-11
影响因子：
10.4
通讯作者：
Marzia V
中科院分区：
文献类型：
--
作者：
Mastrangelo G;Fadda E;Marzia V
暴露在多环芳烃(PAHs)中的各种物质和工业过程的替代品目前被归类为人类致癌物质。本文回顾了最近的流行病学研究，报道了多环芳烃在职业暴露的受试者中致癌作用的直接证据。当对多环芳烃进行定量测量时，肺癌和膀胱癌的风险与剂量有关，并选择真正的非暴露组进行比较。这些新发现表明，目前苯可溶物0.2毫克/立方米的阈值限值(表明接触多环芳烃)是不可接受的，因为在暴露40年后，患肺癌的相对风险为1.2-1.4，膀胱癌的相对风险为2.2。
Various substances and industrial processes, surrogates of exposure to polycyclic aromatic hydrocarbons (PAHs), are currently classified as human carcinogens. This paper reviews recent epidemiological studies reporting direct evidence of the carcinogenic effects of PAHs in occupationally exposed subjects. Risks of lung and bladder cancer were dose dependent when PAHs were measured quantitatively and truly nonexposed groups were chosen for comparison. These new findings suggest that the current threshold limit value of 0.2 mg/m3 of benzene soluble matter (which indicates PAH exposure) is unacceptable because, after 40 years of exposure, it involves a relative risk of 1.2-1.4 for lung cancer and 2.2 for bladder cancer.